Nature Reviews Cancer 11, 211-218 (March 2011) | doi:10.1038/nrc3017

OpinionMolecular targets of phytochemicals for cancer prevention

Ki Won Lee1,3, Ann M. Bode2,3 & Zigang Dong2  About the authors


Although successful for a limited number of tumour types, the efficacy of cancer therapies, especially for late-stage disease, remains poor overall. Many have argued that this could be avoided by focusing on cancer prevention, which has now entered the arena of targeted therapies. During the process of identifying preventive agents, dietary phytochemicals, which are thought to be safe for human use, have emerged as modulators of key cellular signalling pathways. The task now is to understand how these chemicals perturb these pathways by modelling their interactions with their target proteins.

Author affiliations

  1. Ki Won Lee is at the Department of Bioscience and Biotechnology, Konkuk University, Seoul 143701, Republic of Korea, and the Department of Agricultural Biotechnology, Seoul National University, Seoul 151921, Republic of Korea.
  2. Ann M. Bode and Zigang Dong are at The Hormel Institute, University of Minnesota, Austin MN 55,912, USA.
  3. K.W.L. and A.M.B. contributed equally to this work.

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Published online 10 February 2011