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Two studies describe different roles for HIF2α in cancer. It can promote tumorigenesis by mediating the infiltration of tumour-associated macrophages or suppress tumour development by increasing transcription of the tumour suppressorSCGB3A1.
Antibody-based proteomics facilitates the high-throughput evaluation of candidate biomarkers. What insights can be gained, and what are the clinical applications of antibody-based proteomics?
Proteomics approaches are increasingly being used to functionally characterize proteins and signalling pathways, including the roles of complexes and post-translational modifications. This Review illustrates how these techniques have been used to find new aspects of receptor tyrosine kinase-mediated signal transduction pathways in cancer.
This Review focuses on activity-based protein profiling, which enables the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumour cells. When ABPP is integrated with other large-scale profiling methods, it can provide insight into the metabolic and signalling pathways that support cancer pathogenesis and indicate new strategies for treatment.
Combining image analysis with mass spectrometry techniques provides new possibilities for molecular pathology. What are the applications of imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI)?
The integration of existing national and institutional biobanks is required to form larger resources that can be used to study the complexity and heterogeneity of cancer. This article discusses the main practical and ethical issues associated with the integration of biobanks for cancer research.
Proteomics approaches to characterize various aspects of cancer have increased as technology has improved. What are the challenges to cancer proteomics research and what could the future hold?
This Focus issue of specially-commissioned articles reflects the recent insights gained from proteomics in understanding the molecular biology of cancer, and the future promise of applying proteomics to the clinic.
