ACUTE MYELOID LEUKAEMIA, M2 SUBTYPE Classification of acute myeloid leukaemia. The M2 subtype is characterized by predominance of granulated blasts. Differentiaton beyond the promyelocyte stage might be present.
CHAPS A type of histone deacetylase inhibitor in which a hydroxamic-acid moiety is linked to a cyclic tetrapeptide analogue of trapoxin.
CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR (COUP-TF). An orphan nuclear receptor that represses transcription of many genes and associates with HDACs.
CpG ISLAND DNA region of >500 base pairs that has a high CpG density and is usually unmethylated. CpG islands are found upstream of many mammalian genes; methylation leads to transcriptional silencing.
HUS1/RAD9 These proteins were identified by their sensitivity to hydroxyurea and radiation, respectively. They form a complex, involving HDAC1, in G2/M checkpoint control.
MYELODYSPLASTIC SYNDROME Considered to be preleukaemic, this syndrome is characterized by disordered haematopoiesis, with a decrease in mature white blood cells, platelets and erythrocytes.
PHASE I CLINICAL TRIAL A trial designed primarily to evaluate toxicity of a new therapeutic agent and to determine the maximal 'safe' dose.
PHASE II CLINICAL TRIAL A trial designed to determine if a 'safe' dose of a new therapeutic agent is effective in treating disease.
