Review
Nature Reviews Cancer 1, 99-108 (November 2001) | doi:10.1038/35101056
Pharmacogenetics and cancer therapy
Mary V. Relling1,2 & Thierry Dervieux2 About the authors
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Abstract
Pharmacogenetics is the study of how genetic variations affect drug response. These variations can affect a patient's response to cancer drugs, for which there is usually a fine line between a dosage that has a therapeutic effect and one that produces toxicity. Gaining better insight into the genetic elements of both the patient and the tumour that affect drug efficacy will eventually allow for individualized dosage determination and fewer adverse effects.
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Author affiliations
- Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.
- University of Tennessee College of Pharmacy, Memphis, Tennessee 38183, USA.
Correspondence to: Mary V. Relling1,2 Email: mary.relling@stjude.org
