Nature Reviews Cancer

Volume 17, No 8 August 2017

Featured Article

Drugging the 'undruggable' cancer targets

Chi V. Dang, E. Premkumar Reddy, Kevan M. Shokat & Laura Soucek

Front cover of the current issue of Nature Reviews Cancer

2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28

Next issue date: 24 August 2017

Current Issue

Poster

Multifaceted effects of the microenvironment on tumour progression

Daniela F. Quail and Johanna A. Joyce

This poster covers our current understanding of how the different cell types in the tumour microenvironment can contribute to the multiple stages of tumour progression and how considering interactions between tumour cells and the tumour microenvironment is critical to optimize therapeutic strategies.

Current Issue

Review

Microenvironmental regulation of tumour angiogenesis


Michele De Palma, Daniela Biziato & Tatiana V. Petrova

This Review discusses the extrinsic regulation of angiogenesis by the tumour microenvironment, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.

Current Issue

Review

Novel insights into mesothelioma biology and implications for therapy

Timothy A. Yap, Joachim G. Aerts, Sanjay Popat & Dean A. Fennell

Our understanding of mesothelioma pathobiology has increased dramatically in the past 5 years, with an improvement in our knowledge of mesothelioma genetics, epigenetics, tumour microenvironment and immunobiology. This Review discusses these advances and how they might affect therapeutic strategies.

Current Issue

Opinion

Fragile sites in cancer: more than meets the eye


Thomas W. Glover, Thomas E. Wilson & Martin F. Arlt

This Opinion article discusses recent studies that have provided new insights into the mechanisms of common fragile site instability and the resulting genomic effects, which include the generation of focal copy number alterations that affect the genomic landscape of many cancers.

Current Issue

Viewpoint

Drugging the 'undruggable' cancer targets

Chi V. Dang, E. Premkumar Reddy, Kevan M. Shokat & Laura Soucek

In this Viewpoint article, we asked four scientists working to target important, but so-called 'undruggable', proteins in cancer for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of cancer research.

More Cancer

  • Web Focus Collection

    Selected articles from Nature Reviews Cancer and the Nature Research on key topics.

  • Article Series

    A special series of articles that explores a specific theme in the field of cancer research and that are published over a defined period of time.

  • Nature Milestones series

    Collections of key discoveries that have shaped different scientific fields.

  • Cancer@nature.com

    More articles on cancer from the Nature Research.

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Cancer conferences

Click here to find out which meetings will be attended by the editors of Nature Reviews Cancer in 2017.

Poster on Multifaceted effects of the microenvironment on tumour progression

This poster covers our current understanding of how the different cell types in the tumour microenvironment can contribute to the multiple stages of tumour progression and how considering interactions between tumour cells and the tumour microenvironment is critical to optimize therapeutic strategies.

Focus on Tumour metabolism

October and November 2016
This Focus on Tumour metabolism comprises specially-commissioned articles that tackle the metabolism of key nutrients and metabolic reprogramming that are important in tumour growth and survival, while also considering implications for the clinic.

Series on Cancer origins

A clearer understanding of the biological underpinnings of cancer origins might help us design more effective cancer prevention methods or improve early detection of tumours that are likely to become malignant. Furthermore, delineating the cell of origin of a specific tumour and the evolutionary changes that underlie its development should also improve our ability to effectively treat that tumour. This series of articles takes a look at recent progress in the diverse fields that have provided insights into this intriguing problem in cancer biology.

Series of Comment articles on Clinical insights

Clinical studies can teach us a great deal about the processes and mechanisms underlying cancer, and they also remind us of aspects of cancer that we still do not understand. Nature Reviews Cancer's Series of Comment articles on Clinical insights aims to discuss informative findings from the clinic that are often overlooked by laboratory-based cancer researchers. Thinking more broadly about these more unusual aspects of cancer might help us overcome some of the current stumbling blocks in cancer research.

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Focus on Tumour immunology & immunotherapy

This joint Focus issue from Nature Reviews Cancer and Nature Reviews Immunology features specially commissioned articles that discuss the promise of immunotherapy to treat cancer and how key immune cells function in the tumour microenvironment.

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