Carl Conway

New perspectives for targeting RAF kinase in human cancer

Zoi Karoulia, Evripidis Gavathiotis & Poulikos I. Poulikakos

Latest Reviews

  • Review |

    Sphingolipids, specifically ceramide and sphingosine-1-phosphate, have opposing roles in regulating cancer cell death and survival, respectively. This Review discusses the mechanistic and clinical studies of sphingolipid signalling and metabolism in cancer, highlighting current and emerging therapeutic strategies to target these bioactive lipids.

    • Besim Ogretmen
  • Review |

    This Review by Dewhirst and Secomb describes the current understanding of drug transport to tumour cells and the progress that has been made in developing methods to enhance drug delivery.

    • Mark W. Dewhirst
    •  & Timothy W. Secomb
  • Analysis |

    This Analysis examines preclinical mouse tumour studies published in eight scientific journals in 2016. It reviews current practices, identifies some important challenges and discusses ways in which the relevance, reproducibility and translatability of tumour models could be improved.

    • Nicolas Gengenbacher
    • , Mahak Singhal
    •  & Hellmut G. Augustin
  • Review |

    Small-cell lung cancer is an aggressive form of lung cancer and has been difficult to treat due to therapy resistance. This Review discusses challenges and recent advances in uncovering molecular changes that allow potentially efficient therapies.

    • Adi F. Gazdar
    • , Paul A. Bunn
    •  & John D. Minna
  • Review |

    Despite advances in targeting oncogenic driver mutations, advanced-stage non-small-cell lung cancer (NSCLC) remains largely incurable due to therapeutic resistance. This Review focuses on how understanding the mechanisms of resistance to targeted therapies in NSCLC can inform improved treatment strategies.

    • Julia Rotow
    •  & Trever G. Bivona
  • Review |

    The adenosinergic pathway is a major immunosuppressive mechanism in the tumour microenvironment. In this Review, Vijayan et al. discuss how targeting components involved in the generation and downstream signalling of extracellular adenosine represents an attractive novel cancer therapy.

    • Dipti Vijayan
    • , Arabella Young
    • , Michele W.L. Teng
    •  & Mark J. Smyth

News & Comment

  • Research Highlight |

    Mello et al. analysed the effects of various p53 transactivation domain mutants in pancreatic ductal adenocarcinoma and uncovered a crucial tumour-suppressive pathway in which p53 mediates inhibition of the transcriptional co-activator YAP.

    • Sarah Seton-Rogers
  • Research Highlight |

    Sympathetic nerves associate with tumours and regulate the tumour microenvironment. How this innervation promotes tumorigenesis is unclear. A new study in Science shows that β-adrenergic signalling controls tumour growth by promoting tumour angiogenesis, through the regulation of vascular metabolism.

    • Ulrike Harjes
  • Research Highlight |

    The importance of 'Warburgian' metabolism in cancer is an increasingly disputed topic. By studying cancer metabolism in patients and mouse models, Faubert et al. now show that lactate is used as a respiratory fuel in non-small-cell lung cancer in vivo.

    • Ulrike Harjes
  • Research Highlight |

    Kong et al. report a mechanism that underlies tumour 'drug addiction' in melanoma cell lines and mouse models involving an ERK2-dependent phenotype switch, which might have clinical implications for the use of alternating treatment strategies with targeted therapies.

    • Conor A. Bradley
  • Research Highlight |

    A recent study shows that smoking-induced epigenetic changes in lung epithelium occur even before malignant transformation, and sensitize the cells to allow a single key oncogenic event to initiate the growth of a tumour.

    • Ulrike Harjes

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