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3D cell motion on a sagittal section of a mid-gastrulation Xenopus laevis embryo. Red arrows designate maximum cell speed (∼4 μm min1): mesendodermal leading-edge runners (top center); endodermal wall of inflating archenteron (left); blastopore (bottom center). Note pronounced vegetal rotation on lower right and epibolic movement throughout the periphery. Image from the protocol by Moosmann et al. doi: 10.1038/nprot.2014.033. Cover design by Jamel Wooten.