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Microfluidic devices are becoming increasingly important tools for single-molecule spectroscopy. The figure shows an electron micrograph of a microfabricated filter post array designed to prevent small particles from entering a microfluidic mixing device and from blocking the narrow channels in the mixing region. Image taken from the protocol by Wunderlich et al. doi: 10.1038/nprot.2013.082. Cover design by Jamel Wooten.