Protocol abstract
Nature Protocols 3, - 1 - 7 (2008)
Published online: 20 December 2007 | doi:10.1038/nprot.2007.453
Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions
Nicholas E Leadbeater1 & Jason R Schmink1
Abstract
The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.
- Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA.
Correspondence to: Nicholas E Leadbeater1 e-mail: nicholas.leadbeater@uconn.edu
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- 10-ml Reaction vessels(CEM Corporation)
- Büchner funnel(Fisher)
- Caps for reaction vessels(CEM Corporation)
- Cyclohexane(Aldrich)
- Discover S-Class microwave unit(CEM Corporation)
- Disposable glass pipettes(Fisher)