Box 1. Advantages of Microwave Synthesis
From the following article
Doris Dallinger & C Oliver Kappe
Nature Protocols 2, 317 - 321 (2007) Published online: 1 March 2007
doi:10.1038/nprot.2006.436
- Higher reaction temperatures can be obtained by combining rapid microwave heating with sealed-vessel (autoclave) technology.
- In many instances significantly reduced reaction times, higher yields and cleaner reaction profiles will be experienced, allowing for more rapid reaction optimization and library synthesis.
- Lower boiling solvents can be used under pressure (closed-vessel conditions) and be heated at temperatures considerably higher than their boiling point.
- Microwave heating allows direct 'in core' heating of the reaction mixture, which results in a faster and more even heating of the reaction mixture.
- Easy online control of temperature and pressure profiles is possible, which leads to more reproducible reaction conditions.
- Can easily be adapted to automated sequential synthesis.
