Protocol abstract
Nature Protocols 1, - 2590 - 2595 (2006)
Published online: 11 January 2007 | doi:10.1038/nprot.2006.441
Subject Category: Synthetic chemistry
Preparation of substituted anilines from nitro compounds by using supported gold catalysts
Abstract
A protocol for the chemoselective hydrogenation of nitro compounds to the corresponding anilines by means of supported gold catalysts is described. Nitro groups on different compounds — containing double bonds, carbonyl, nitrile or amide groups — have been successfully hydrogenated on supported gold nanoparticles (Au/TiO2 and Au/Fe2O3), using a batch reactor under H2 pressure. Unlike other noble metals, gold shows high chemoselectivity towards reduction of the nitro group, at near-complete conversion of the substrate. The total time to carry out this protocol strongly depends on the reaction step, which is a function of the activity of the catalyst and the nature of the substrate.
- Instituto de Tecnología Química, UPV-CSIC, Av. los Naranjos, s/n, Valencia 46022, Spain.
Correspondence to: Avelino Corma1 e-mail: acorma@itq.upv.es
nature-products
A-Z product listing
- 1-Nitro-1-Cyclohexene(Aldrich)
- 2 ml encapsulated glass vials(Scharlab)
- 3-Nitrostyrene(Aldrich)
- 4-Nitrobenzaldehyde(Aldrich)
- 4-Nitrobenzamide(Aldrich)
- 4-Nitrobenzonitrile(Fluka)
