Neuropsychopharmacology

TABLE 2

FROM:

Long-Term Effects of Nucleus Accumbens Deep Brain Stimulation in Treatment-Resistant Depression: Evidence for Sustained Efficacy

Bettina H Bewernick, Sarah Kayser, Volker Sturm and Thomas E Schlaepfer

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Table 2. Psychopathological Measures at Multiple Time Points During DBS Treatment

 Baseline1 Month3 Months6 Months9 Months12 Months15 Months18 Months21 Months24 MonthsLast observation
 Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)
 p-Value main effectp-Valuep-Valuep-Valuep-Valuep-Valuep-Valuep-Valuep-Valuep-Valuep-Value
HDRS_28
Group32.2 (5.5)23.2 (5.6)23.4 (5.1)20.9 (4.6)23.3 (5.5)20.2 (7.5)21.3 (7.1)21 (8.9)21.5 (8.1)19.5 (9)22.1(13.4)
F=4.1p<0.001p<0.005p<0.001p=0.001p<0.005p<0.005p<0.005p<0.005p<0.01p<0.01p<0.05
df=10
            
MADRS
Group32.3 (3.7)24.2 (4.8)23.4 (4.7)20.9 (5.6)22.8 (6.8)20.2 (7.3)21.2 (7.8)21.1 (8.5)21.7 (9.3)19.1 (8.5)21.6 (10.7)
F=5.1p<0.001p<0.001p<0.001p<0.001p<0.005p=0.001p<0.005p<0.005p<0.05p<0.005p<0.05
df=10
            
HAMA
Group23.3 (5.7)17.9 (7.3)17.6 (5.9)15.4 (3.9)17.4 (3)14.3 (5.8)15.7 (9)16 (10.4)13.7 (6.4)13.9 (4.9)14.7 (8.8)
F=2.7p<0.005p<0.01p<0.05p<0.005p<0.005p<0.005p<0.05p<0.05p<0.005p=0.001p<0.05
df=10
            
Activities
Group28.5 (16)43.9 (24.8)39 (21.8)41.6 (24.4)43.2 (20.5)45.7 (20.7)45.5 (25.4)46.4 (25.3)48 (29.6)51.9 (35.5)57.9 (37.7)
F=2.4p<0.05p<0.05p<0.05p=0.100p<0.05p<0.05p=0.052p<0.05p=0.075p=0.083p<0.05
df=10
            
SF 36
Mental health
Group19.4 (4.9)23.3 (6.3) 19.5 (3.4) 20.5 (6.5) 19.9 (3.8) 24.3 (11.4)29.9 (11.2)
F=4.9p<0.001p<0.05 p=0.953 p=0.551 p=0.749 p=0.172p<0.05
df=6
            
Physical health
Group34.0 (4.5)35.4 (7.9) 38.0 (5.9) 35.7 (4.6) 34.8 (3.9) 37.6 (8.5)34.1 (13.3)
F=0.7p=0.651p=0.42 p=0.40 p=0.267 p=0.565 p=0.182p=0.980
df=6

 Abbreviations: Activities, number of positive activities after Hautzinger; HAMA, Hamilton Anxiety Scale; HDRS_28, Hamilton-28-Items Depression Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; SF-36, Health Survey Questionnaire.

 Mean, SD, ANOVAs for repeated measures with the factor time and post-hoc contrasts for each time point in comparison with baseline.

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