Neuropsychopharmacology

FIGURES AND TABLES

FROM:

Long-Term Effects of Nucleus Accumbens Deep Brain Stimulation in Treatment-Resistant Depression: Evidence for Sustained Efficacy

Bettina H Bewernick, Sarah Kayser, Volker Sturm and Thomas E Schlaepfer

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Figure 1.

Clinical outcomes over time. Hamilton depression rating over time (top left); Montgomery-Asperg rating over time (top right); positive activities over time (bottom left); Hamilton anxiety rating over time (bottom right). In red responders (>50% reduction from baseline), in blue non-responders (<50% reduction from baseline), in green group mean scores. For the activities, panel red refers to patients who responded >50% in the HDRS score. At each time point, 11 patients contributed, as data were analyzed in an intent-to-treat method with last observation carried forward.

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Figure 2.

Stability of clinical effect. Individual response over time. Red lines are responders (>50% reduction from baseline), n=5, in blue non-responders (<50% reduction from baseline), n=6, at time points 12 and 24 months. Diamonds represent corresponding group mean values.

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