TABLE OF CONTENTS
Volume 34, Issue 4 (March 2009)
Commentary
Accruing Preclinical Evidence about Metabotropic Glutamate 5 Receptor Antagonists as Treatments for Drug Dependence Highlights the Irreplaceable Contributions of Animal Studies to the Discovery of New Medications for Human Disorders
Athina Markou
Neuropsychopharmacology 34: 817-819; advance online publication, December 17, 2008; doi:10.1038/npp.2008.218
Original Articles
mGluR5 Antagonism Attenuates Methamphetamine Reinforcement and Prevents Reinstatement of Methamphetamine-Seeking Behavior in Rats
Justin T Gass, Megan P H Osborne, Noreen L Watson, Jordan L Brown and M Foster Olive
Neuropsychopharmacology 34: 820-833; advance online publication, September 17, 2008; doi:10.1038/npp.2008.140
The Medial Prefrontal Cortex Regulates the Differential Expression of Morphine-Conditioned Place Preference Following a Single Exposure to Controllable or Uncontrollable Stress
Robert R Rozeske, Andre Der-Avakian, Sondra T Bland, Jacob T Beckley, Linda R Watkins and Steven F Maier
Neuropsychopharmacology 34: 834-843; advance online publication, March 26, 2008; doi:10.1038/npp.2008.34
A Differential Role for the Adenosine A2A Receptor in Opiate Reinforcement vs Opiate-Seeking Behavior
Robyn Mary Brown, Jennifer Lynn Short, Michael Scott Cowen, Catherine Ledent and Andrew John Lawrence
Neuropsychopharmacology 34: 844-856; advance online publication, June 4, 2008; doi:10.1038/npp.2008.72
Narp Deletion Blocks Extinction of Morphine Place Preference Conditioning
Hans S Crombag, Mercy Dickson, Megan Dinenna, Alexander W Johnson, Mark S Perin, Peter C Holland, Jay M Baraban and Irving M Reti
Neuropsychopharmacology 34: 857-866; advance online publication, June 4, 2008; doi:10.1038/npp.2008.80
Increased OPRM1 DNA Methylation in Lymphocytes of Methadone-Maintained Former Heroin Addicts
David A Nielsen, Vadim Yuferov, Sara Hamon, Colin Jackson, Ann Ho, Jurg Ott and Mary Jeanne Kreek
Neuropsychopharmacology 34: 867-873; advance online publication, July 23, 2008; doi:10.1038/npp.2008.108
The Ventral Pallidum is Critically Involved in the Development and Expression of Morphine-Induced Sensitization
Amanda L Mickiewicz, Jeanine E Dallimore and T Celeste Napier
Neuropsychopharmacology 34: 874-886; advance online publication, July 30, 2008; doi:10.1038/npp.2008.111
Augmentation of Morphine-Induced Sensitization but Reduction in Morphine Tolerance and Reward in Delta-Opioid Receptor Knockout Mice
V I Chefer and T S Shippenberg
Neuropsychopharmacology 34: 887-898; advance online publication, August 13, 2008; doi:10.1038/npp.2008.128
Mechanisms of Withdrawal-Associated Increases in Heroin Self-Administration: Pharmacologic Modulation of Heroin vs Food Choice in Heroin-Dependent Rhesus Monkeys
S Stevens Negus and Kenner C Rice
Neuropsychopharmacology 34: 899-911; advance online publication, August 13, 2008; doi:10.1038/npp.2008.127
Behavioral and Neurochemical Changes Induced by Oxycodone Differ Between Adolescent and Adult Mice
Yong Zhang, Roberto Picetti, Eduardo R Butelman, Stefan D Schlussman, Ann Ho and Mary Jeanne Kreek
Neuropsychopharmacology 34: 912-922; advance online publication, September 10, 2008; doi:10.1038/npp.2008.134
Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication
M C Wichers, D Q C M Barge-Schaapveld, N A Nicolson, F Peeters, M de Vries, R Mengelers and J van Os
Neuropsychopharmacology 34: 923-931; advance online publication, May 21, 2008; doi:10.1038/npp.2008.66
Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects
Simone Grimm, Peter Boesiger, Johannes Beck, Daniel Schuepbach, Felix Bermpohl, Martin Walter, Jutta Ernst, Daniel Hell, Heinz Boeker and Georg Northoff
Neuropsychopharmacology 34: 932-843; advance online publication, June 4, 2008; doi:10.1038/npp.2008.81
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Lara G Chepenik, Carolyn Fredericks, Xenophon Papademetris, Linda Spencer, Cheryl Lacadie, Fei Wang, Brian Pittman, James S Duncan, Lawrence H Staib, Ronald S Duman, Joel Gelernter and Hilary P Blumberg
Neuropsychopharmacology 34: 944-951; advance online publication, August 13, 2008; doi:10.1038/npp.2008.107
Antidepressants Influence Somatostatin Levels and Receptor Pharmacology in Brain
Eleftherios Pallis, Anna Vasilaki, Dominique Fehlmann, Andreas Kastellakis, Daniel Hoyer, Christina Spyraki and Kyriaki Thermos
Neuropsychopharmacology 34: 952-963; advance online publication, September 17, 2008; doi:10.1038/npp.2008.133
Two-Week Treatment With the Selective Serotonin Reuptake Inhibitor Citalopram Reduces Contextual Anxiety but Not Cued Fear in Healthy Volunteers: A Fear-Potentiated Startle Study
Christian Grillon, Chanen Chavis, Matthew F Covington and Daniel S Pine
Neuropsychopharmacology 34: 964-971; advance online publication, September 17, 2008; doi:10.1038/npp.2008.141
Dopamine D2 and Adenosine A2A Receptors Regulate NMDA-Mediated Excitation in Accumbens Neurons Through A2A–D2 Receptor Heteromerization
Karima Azdad, David Gall, Amina S Woods, Catherine Ledent, Sergi Ferré and Serge N Schiffmann
Neuropsychopharmacology 34: 972-986; advance online publication, September 17, 2008; doi:10.1038/npp.2008.144
Desipramine Modulation of 
-, 
-Synuclein, and the Norepinephrine Transporter in an Animal Model of Depression
Alexis M Jeannotte, John G McCarthy, Eva E Redei and Anita Sidhu
Neuropsychopharmacology 34: 987-998; advance online publication, September 17, 2008; doi:10.1038/npp.2008.146
Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy
Henricus G Ruhé, Jan Booij, Henk C v Weert, Johannes B Reitsma, Eric J F Fransen, Martin C Michel and Aart H Schene
Neuropsychopharmacology 34: 999-1010; advance online publication, October 1, 2008; doi:10.1038/npp.2008.148
-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency
Yolanda de Diego-Otero, Yanina Romero-Zerbo, Rajaa el Bekay, Juan Decara, Lourdes Sanchez, Fernando Rodriguez-de Fonseca and Ignacio del Arco-Herrera
Neuropsychopharmacology 34: 1011-1026; advance online publication, October 8, 2008; doi:10.1038/npp.2008.152
Response Perseveration and Ventral Prefrontal Sensitivity to Reward and Punishment in Male Problem Gamblers and Smokers
Michiel B de Ruiter, Dick J Veltman, Anna E Goudriaan, Jaap Oosterlaan, Zsuzsika Sjoerds and Wim van den Brink
Neuropsychopharmacology 34: 1027-1038; advance online publication, October 1, 2008; doi:10.1038/npp.2008.175
Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization
Alain Gobert, Mauricette Brocco, Anne Dekeyne, Benjamin Di Cara, Gaëlle Bouchez, Françoise Lejeune, Robert L Gannon and Mark J Millan
Neuropsychopharmacology 34: 1039-1056; advance online publication, October 1, 2008; doi:10.1038/npp.2008.176
Programmed Acute Electrical Stimulation of Ventral Tegmental Area Alleviates Depressive-Like Behavior
Alexander Friedman, Michael Frankel, Yakov Flaumenhaft, Avia Merenlender, Albert Pinhasov, Yuval Feder, Michal Taler, Irit Gil-Ad, Moshe Abeles and Gal Yadid
Neuropsychopharmacology 34: 1057-1066; advance online publication, October 8, 2008; doi:10.1038/npp.2008.177
Postsynaptic -2 Adrenergic Receptors are Critical for the Antidepressant-Like Effects of Desipramine on Behavior
Han-Ting Zhang, Lisa R Whisler, Ying Huang, Yang Xiang and James M O'Donnell
Neuropsychopharmacology 34: 1067-1066; advance online publication, October 15, 2008; doi:10.1038/npp.2008.184
The Dopamine D2 Receptors in High-Affinity State and D3 Receptors in Schizophrenia: A Clinical [11C]-(+)-PHNO PET Study
Ariel Graff-Guerrero, Romina Mizrahi, Ofer Agid, Heidi Marcon, Penny Barsoum, Pablo Rusjan, Alan A Wilson, Robert Zipursky and Shitij Kapur
Neuropsychopharmacology 34: 1078-1086; advance online publication, November 5, 2008; doi:10.1038/npp.2008.199
Erratum
Increased OPRM1 DNA Methylation in Lymphocytes of Methadone FREE
David A Nielsen, Vadim Yuferov, Sara Hamon, Colin Jackson, Ann Ho, Jurg Ott and Mary Jeanne Kreek
Neuropsychopharmacology 34: 1087; doi:10.1038/npp.2008.155
Corrigendum
Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial with Assessment of Serotonin Transporter Occupancy FREE
Henricus G Ruhé, Jan Booij, Henk C v Weert, Johannes B Reitsma, Eric JF Fransen, Martin C Michel and Aart H Schene
Neuropsychopharmacology 34: 1088; doi:10.1038/npp.2008.213
