TABLE OF CONTENTS

Volume 33, Issue 9 (August 2008)

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Institute of Medicine Forum on Drug Discovery, Development, and Translation

Grand Challenges for Psychiatric Drug Discovery: A Perspective FREE

Linda S Brady, Robert B Giffin, Janet Woodcock, Gail H Cassell and Edward W Holmes

Neuropsychopharmacology 33: 2047; doi:10.1038/npp.2008.54

Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings FREE

P Jeffrey Conn and Bryan L Roth

Neuropsychopharmacology 33: 2048-2060; advance online publication, January 23, 2008; doi:10.1038/sj.npp.1301638

The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities FREE

William T Carpenter and James I Koenig

Neuropsychopharmacology 33: 2061-2079; advance online publication, November 28, 2007; doi:10.1038/sj.npp.1301639

Novel Drugs and Therapeutic Targets for Severe Mood Disorders FREE

Sanjay J Mathew, Husseini K Manji and Dennis S Charney

Neuropsychopharmacology 33: 2080-2092; advance online publication, January 2, 2008; doi:10.1038/sj.npp.1301652

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Original Articles

Neural Pathways Underlying Lactate-Induced Panic FREE

Philip L Johnson, William A Truitt, Stephanie D Fitz, Christopher A Lowry and Anantha Shekhar

Neuropsychopharmacology 33: 2093-2107; advance online publication, December 5, 2007; doi:10.1038/sj.npp.1301621

Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD FREE

Shigeto Yamamoto, Shigeru Morinobu, Manabu Fuchikami, Akiko Kurata, Toshiro Kozuru and Shigeto Yamawaki

Neuropsychopharmacology 33: 2108-2116; advance online publication, October 24, 2007; doi:10.1038/sj.npp.1301605

Overlapping and Distinct Brain Regions Associated with the Anxiolytic Effects of Chlordiazepoxide and Chronic Fluoxetine FREE

Anita J Bechtholt, Rita J Valentino and Irwin Lucki

Neuropsychopharmacology 33: 2117-2130; advance online publication, November 7, 2007; doi:10.1038/sj.npp.1301616

Spontaneous Nicotine Withdrawal Potentiates the Effects of Stress in Rats FREE

Sietse Jonkman, Victoria B Risbrough, Mark A Geyer and Athina Markou

Neuropsychopharmacology 33: 2131-2138; advance online publication, November 21, 2007; doi:10.1038/sj.npp.1301607

Metabotropic Glutamate 5 Receptor (mGluR5) Antagonists Decrease Nicotine Seeking, But Do Not Affect the Reinforcement Enhancing Effects of Nicotine FREE

Matthew I Palmatier, Xiu Liu, Eric C Donny, Anthony R Caggiula and Alan F Sved

Neuropsychopharmacology 33: 2139-2147; advance online publication, November 28, 2007; doi:10.1038/sj.npp.1301623

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues FREE

Francis J McClernon, Rachel V Kozink and Jed E Rose

Neuropsychopharmacology 33: 2148-2157; advance online publication, November 7, 2007; doi:10.1038/sj.npp.1301618

alpha6-Containing Nicotinic Acetylcholine Receptors Dominate the Nicotine Control of Dopamine Neurotransmission in Nucleus Accumbens FREE

Richard Exley, Michael A Clements, Henrike Hartung, J Michael McIntosh and Stephanie J Cragg

Neuropsychopharmacology 33: 2158-2166; advance online publication, November 21, 2007; doi:10.1038/sj.npp.1301617

Nicotine Effect on Prepulse Inhibition and Prepulse Facilitation in Schizophrenia Patients FREE

L Elliot Hong, Ikwunga Wonodi, Jada Lewis and Gunvant K Thaker

Neuropsychopharmacology 33: 2167-2174; advance online publication, October 24, 2007; doi:10.1038/sj.npp.1301601

Lamina-Specific Abnormalities of NMDA Receptor-Associated Postsynaptic Protein Transcripts in the Prefrontal Cortex in Schizophrenia and Bipolar Disorder FREE

Monica Beneyto and James H Meador-Woodruff

Neuropsychopharmacology 33: 2175-2186; advance online publication, November 21, 2007; doi:10.1038/sj.npp.1301604

Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients FREE

Suzie Lavoie, Micah M Murray, Patricia Deppen, Maria G Knyazeva, Michael Berk, Olivier Boulat, Pierre Bovet, Ashley I Bush, Philippe Conus, David Copolov, Eleonora Fornari, Reto Meuli, Alessandra Solida, Pascal Vianin, Michel Cuénod, Thierry Buclin and Kim Q Do

Neuropsychopharmacology 33: 2187-2199; advance online publication, November 14, 2007; doi:10.1038/sj.npp.1301624

BDNF Levels and Genotype are Associated with Antipsychotic-Induced Weight Gain in Patients with Chronic Schizophrenia FREE

Xiang Yang Zhang, Dong Feng Zhou, Gui Ying Wu, Lian Yuan Cao, Yun Long Tan, Colin N Haile, Jun Li, Lin Lu, Therese A Kosten and Thomas R Kosten

Neuropsychopharmacology 33: 2200-2205; advance online publication, November 7, 2007; doi:10.1038/sj.npp.1301619

Chronic Phenethylamine Hallucinogen Treatment Alters Behavioral Sensitivity to a Metabotropic Glutamate 2/3 Receptor Agonist FREE

Michael A Benneyworth, Randy L Smith and Elaine Sanders-Bush

Neuropsychopharmacology 33: 2206-2216; advance online publication, October 24, 2007; doi:10.1038/sj.npp.1301600

Abnormal Reward System Activation in Mania FREE

Birgit Abler, Ian Greenhouse, Dost Ongur, Henrik Walter and Stephan Heckers

Neuropsychopharmacology 33: 2217-2227; advance online publication, November 7, 2007; doi:10.1038/sj.npp.1301620

Memantine Upregulates BDNF and Prevents Dopamine Deficits in SIV-Infected Macaques: A Novel Pharmacological Action of Memantine FREE

Falko Meisner, Carsten Scheller, Susanne Kneitz, Sieghart Sopper, Eva Neuen-Jacob, Peter Riederer, Volker ter Meulen and Eleni Koutsilieri

Neuropsychopharmacology 33: 2228-2236; advance online publication, October 31, 2007; doi:10.1038/sj.npp.1301615

Interleukin-6 Upregulates Neuronal Adenosine A1 Receptors: Implications for Neuromodulation and Neuroprotection FREE

Knut Biber, A Pinto-Duarte, M C Wittendorp, A M Dolga, C C Fernandes, J Von Frijtag Drabbe Künzel, J N Keijser, R de Vries, A P Ijzerman, J A Ribeiro, U Eisel, A M Sebastião and H W G M Boddeke

Neuropsychopharmacology 33: 2237-2250; advance online publication, November 7, 2007; doi:10.1038/sj.npp.1301612

Intrahippocampal Transplantation of Transgenic Neural Precursor Cells Overexpressing Interleukin-1 Receptor Antagonist Blocks Chronic Isolation-Induced Impairment in Memory and Neurogenesis FREE

Ofra Ben Menachem-Zidon, Inbal Goshen, Tirzah Kreisel, Yair Ben Menahem, Etti Reinhartz, Tamir Ben Hur and Raz Yirmiya

Neuropsychopharmacology 33: 2251-2262; advance online publication, November 7, 2007; doi:10.1038/sj.npp.1301606

Stimulation of alpha 2-Adrenoceptors Suppresses Excitatory Synaptic Transmission in the Medial Prefrontal Cortex of Rat FREE

Xiao-Hua Ji, Jin-Zhao Ji, Hui Zhang and Bao-Ming Li

Neuropsychopharmacology 33: 2263-2271; advance online publication, October 24, 2007; doi:10.1038/sj.npp.1301603

Supply of a Nondrug Substitute Reduces Escalated Heroin Consumption FREE

Magalie Lenoir and Serge H Ahmed

Neuropsychopharmacology 33: 2272-2282; advance online publication, October 31, 2007; doi:10.1038/sj.npp.1301602

Patients with Premenstrual Dysphoric Disorder have Increased Startle Response Across both Cycle Phases and Lower Levels of Prepulse Inhibition During the Late Luteal Phase of the Menstrual Cycle FREE

Kristiina Kask, Maria Gulinello, Torbjörn Bäckström, Mark A Geyer and Inger Sundström-Poromaa

Neuropsychopharmacology 33: 2283-2290; advance online publication, October 17, 2007; doi:10.1038/sj.npp.1301599

Acute Tryptophan Depletion in Healthy Volunteers Enhances Punishment Prediction but Does not Affect Reward Prediction FREE

Roshan Cools, Oliver J Robinson and Barbara Sahakian

Neuropsychopharmacology 33: 2291-2299; advance online publication, October 17, 2007; doi:10.1038/sj.npp.1301598

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Corrigenda

Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings FREE

P Jeffrey Conn and Bryan L Roth

Neuropsychopharmacology 33: 2300; advance online publication, June 4, 2008; doi:10.1038/npp.2008.83

Novel Drugs and Therapeutic Targets for Severe Mood Disorders FREE

Sanjay J Mathew, Husseini K Manji and Dennis S Charney

Neuropsychopharmacology 33: 2300; advance online publication, June 4, 2008; doi:10.1038/npp.2008.84

Antenatal Maternal Anxiety is Related to HPA-Axis Dysregulation and Self-Reported Depressive Symptoms in Adolescence: A Prospective Study on the Fetal Origins of Depressed Mood FREE

Bea R H Van den Bergh, Ben Van Calster, Tim Smits, Sabine Van Huffel and Lieven Lagae

Neuropsychopharmacology 33: 2301; doi:10.1038/sj.npp.1301540

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