1. ¹Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
2. ²Institute of Mental Health, Peking University, Beijing, PR China
3. ³Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Beijing, PR China
4. ⁴College of Pharmacology, Anhui Medical University, Hefei, Anhui Province, PR China
5. ⁵National Institute on Drug Dependence, Peking University, Beijing, PR China

Correspondence: Dr XY Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Research Building 109, Room 130, 2002 Holcombe Boulevard, Houston, Texas 77030, USA. Tel: +1 713-791-1414 ext. 5824; Fax: +1 713-794-7938; E-mail: xyzhang@bcm.edu; Dr DF Zhou, Institute of Mental Health, Peking University, 51 Hua-Yuan-Bei Road, Hai-Dian District, Beijing 100083, PR China. Tel: +86 10 82801998; Fax: +86 10 62027314; E-mail: zhoudf@bjmu.edu.cn

Received 23 May 2007; Revised 3 August 2007; Accepted 3 October 2007; Published online 7 November 2007.

Abstract

Recent evidence suggests that centrally released brain-derived neurotrophic factor (BDNF) modulates eating behavior and metabolism that is responsible for body weight fluctuation. BDNF also may play an important role in the therapeutic action of antipsychotic medications. We investigated whether the Val66Met polymorphism of the BDNF gene affected weight gain after long-term antipsychotic treatment in schizophrenia. The polymorphism was genotyped in 196 Chinese patients with schizophrenia on long-term antipsychotic medication. Serum BDNF was measured in all patients and 50 normal controls. Mean body mass index (BMI) change was evaluated retrospectively by means of clinical records. The results showed that there was a significant relationship between the three BDNF Val/Met genotypes and mean BMI gain, with genotype having a strong effect on BMI gain in male but not female patients. BDNF levels were significantly lower in patients than normal controls, and negatively correlated with BMI gain in female but not male patients. Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females.