Neuropsychopharmacology

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Neuroplasticity Mediated by Altered Gene Expression

Colleen A McClung and Eric J Nestler

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Figure 1.

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Regulation of CREB activity. Stimulation of D1 dopamine receptors and glutamate receptors on striatal neurons activates several second messenger cascades. Shown in the cell nucleus is a model of binding sites from the cFos promoter including a serum response element (SRE), activator protein-1 element (AP-1), and a cyclic AMP (cAMP) response element (CRE). CBP, CREB-binding protein; CREB, cAMP response element binding protein; MAPK, MAP kinase; NMDAR, NMDA receptor; PKA, protein kinase A; TBP, TATA binding protein. Modified from Hyman et al (2006).

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