FIGURE 6
FROM:
The Anticonvulsants Lamotrigine, Riluzole, and Valproate Differentially Regulate AMPA Receptor Membrane Localization: Relationship to Clinical Effects in Mood Disorders
Jing Du, Katsuji Suzuki, Yanling Wei, Yun Wang, Rayah Blumenthal, Zheng Chen, Cynthia Falke, Carlos A Zarate Jr and Husseini K Manji
BACK TO ARTICLEFigure 6.
Chronic treatment with lamotrigine, riluzole, and imipramine in vivo significantly enhance GluR1 phosphorylation at S845. C57/BL/6 mice were treated with lamotrigine (Lam (6), 25 mg/kg, once daily), riluzole (Rilu (6), 10 mg/kg, once daily), and imipramine (Imi (11), 10 mg/kg, twice daily) for 10 days. Hippocampi were isolated from the brain tissue and protein samples were prepared from these brain tissues. Equal amount of proteins were loaded on 10% SDS-PAGE. Phosphorylation of GluR1 S845 was determined by Western blot analysis with an anti-GluR1S845 antibody (a). Total GluR1 were determined and showed no changes among three groups (b). Chronic lamotrigine-, riluzole-, or imipramine-treated animals all showed significantly increased levels of pGluR1 at the S845 site (* p<0.05, ** p<0.01).
