Neuropsychopharmacology

FIGURE 8

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The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats

Eliza Koros, Holger Rosenbrock, Gerald Birk, Carmen Weiss and Frank Sams-Dodd

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Figure 8.

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(a–e) Effects of acute administration of PCP (a), (+)-MK-801 (b), ketamine (c), memantine (d), and MTEP (e) on vertical activity in rats in the motility test. Data represent the mean number of rearings per 120 min +SEM. Numbers of rats in the groups varied from 8 to 12. * p<0.05; ** p<0.01; *** p<0.001 significantly different from the respective control (saline- or vehicle-treated) group.

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