Neuropsychopharmacology

FIGURE 3

FROM:

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Etienne Challet, Sylviane Gourmelen, Paul Pevet, Philippe Oberling and Laure Pain

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Figure 3.

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General locomotor activity (arbitrary units) in rats housed in constant darkness. Successive 24-h periods are double-plotted (48-h horizontal time scale). At circadian time 14, animals in (a and b) were perfused via implanted catheter with propofol (60 mg/kg) and vehicle solution of intralipids, respectively. Note that propofol treatment leads to a subsequent phase-advance in the circadian rhythm of rest-activity, that is not detected after perfusion of the vehicle. Onset of perfusion is indicated by an asterisk.

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