¹Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel

Correspondence: Dr I Akirav, Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. Tel: +972 8 9344418; Fax: +972 8 9344131; E-mail: Irit.Akirav@weizmann.ac.il

Received 12 August 2005; Revised 6 January 2006; Accepted 9 January 2006; Published online 15 March 2006.

Abstract

The ability to extinguish aversive memories is of significant clinical interest. The amygdala plays an important role in emotional conditioning and its experimental extinction. It has been suggested that -aminobutyric acid (GABA) agonists retard extinction and that consolidation of extinction involves N-methyl-D-aspartate receptor (NMDAR)-mediated plasticity. The aim was to further explore the interaction between GABA and NMDA in the amygdala in consolidation of experimental extinction in the rat. To that end conditioned taste aversion (CTA) was used. In CTA, the amygdala has been reported to subserve both acquisition and extinction. The GABA_A receptor agonist, muscimol, administered into the amygdala immediately after the first extinction session, caused lasting disruption of extinction of CTA for at least 2 weeks. However, the administration of GABA_A receptor antagonists had no effect on extinction kinetics. Microinfusing the partial NMDA agonist D-cycloserine together with or after muscimol infusion reversed the blocking effects of muscimol. These findings could bear relevance to the potential involvement of extinction abnormalities in behavioral disorders, and their amelioration.