FIGURE 3
FROM:
High-Dose Methadone Maintenance in Rats: Effects on Cocaine Self-Administration and Behavioral Side Effects
Francesco Leri, Robert E Sorge, Erin Cummins, David Woehrling, James G Pfaus and Jane Stewart
BACK TO ARTICLEFigure 3.
(a) Mean (SEM) responses emitted by rats implanted with vehicle- and methadone-filled minipumps on the last day of cocaine (0.5 mg/kg/infusion) self-administration on a continuous schedule of reinforcement (FR1 (5)), and on the four subsequent sessions of cocaine (same dose) self-administration on a PR schedule. (b) Mean (SEM) infusions in the same rats, under the same conditions. The # indicates significant within-group differences from the last day of self-administration on a continuous schedule of reinforcement (FR1 (5)). The * indicates a significant difference between rats maintained on 30 mg/kg/day methadone and rats maintained on vehicle.
