TABLE 1

FROM:

Dopamine Transporter Gene (DAT1) Associated with Appetite Suppression to Methylphenidate in a Case–Control Study of Binge Eating Disorder

Caroline Davis, Robert D Levitan, Allan S Kaplan, Jacqueline Carter, Caroline Reid, Claire Curtis, Karen Patte and James L Kennedy

Table 1. A Proposed Theory of Associations among the Dopamine Transporter, the Dopamine Signal, and Psycho-Behavioral Response

10-repeat	Protein synaptic DA	Increased risk for ADHD and therapeutic response to MP; increased euphoric response to exogenous stimulants
9-repeat	Protein synaptic DA	Increased risk for cocaine paranoia and binge eating
DA signal	Hedonic tone and sensitivity to reward	Increased risk for drug addiction
DA signal	Hedonic tone and sensitivity to reward	Increased risk for overeating