TABLE 1

FROM:

Lack of Pharmacokinetic Interaction between Oxcarbazepine and Lamotrigine

Jochen G W Theis, Jagdev Sidhu, Joanne Palmer, Sarah Job, Jonathan Bullman and John Ascher

Table 1. Pharmacokinetics of Lamotrigine, Oxcarbazepine, and MHD

	Geometric mean (range)
	Regimen A	Regimen B
	+OXC	+PBO	Ratio (90% CI)
LTG	(n=13)	(n=13)	A : B	CVb (%)
C max (ng/ml)	4411 (2905–6514)	4479 (3176–5906)	0.98 (0.85, 1.15)	22.8
AUC0–24 (ng h/ml)	64202 (44676–98924)	69754 (51697–104027)	0.92 (0.78, 1.08)	24.7
t max (h)a	1.00 (0.50–2.00)	1.50 (0.50–4.00)	—	—

	Regimen A	Regimen C
	+LTG	+PBO
MHD	(n=13)	(n=13)	A : C
C max (g/ml)	19.0 (13.8–23.1)	19.7 (15.3–25.1)	0.96 (0.88, 1.06)	14.6
AUC0–12 (g h/ml)	192 (143–239)	204 (158–258)	0.94 (0.86, 1.04)	13.8
t max (h)a	3.00 (1.00–4.00)	3.00 (1.50–8.00)	—	—

	Regimen A	Regimen C	—	—
	+LTG	+PBO
OXC	(n=13)	(n=13)
C max (g/ml)	1.52 (0.73–2.95)	1.66 (0.91–2.74)	—	—
AUC0–12 (g h/ml)	6.44 (4.49–9.43)	7.06 (5.00–9.03)	—	—
t max (h)a	1.00 (0.50–3.00)	1.00 (0.50–3.00)	—	—

^a Median (range).

 LTG=lamotrigine; MHD=10-monohydroxy metabolite of OXC; OXC=oxcarbazepine; CI=confidence interval; CVb=between-subject variability.