Neuropsychopharmacology

TABLE 1

FROM:

Circadian Clock-Related Polymorphisms in Seasonal Affective Disorder and their Relevance to Diurnal Preference

Carolina Johansson, Matthäeus Willeit, Christina Smedh, Jenny Ekholm, Tiina Paunio, Tuula Kieseppä, Dirk Lichtermann, Nicole Praschak-Rieder, Alexander Neumeister, Lars-Göran Nilsson, Siegfried Kasper, Leena Peltonen, Rolf Adolfsson, Martin Schalling and Timo Partonen

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Table 1. Genotyping of SAD Patients and Matched Controls

 GenotypeSAD (n=159)Controls (n=159) chi 2 (P value)
CLOCK 3111 T/T 79 (50%)75 (47%)0.21 (0.90)
  C/T 72 (45%)76 (48%) 
  C/C 8 (5%)8 (5%) 
     
Period2 1244 Gly/Gly 120 (75%)111 (70%)3.44 (0.18)
  Gly/Glu 34 (21%)46 (29%) 
  Glu/Glu 5 (3%)2 (1%) 
     
Period3 647 Val/Val 95 (60%)102 (64%)1.29 (0.52)
  Gly/Val 58 (36%)49 (31%) 
  Gly/Gly 6 (4%)8 (5%) 
     
NPAS2 471 Ser/Ser 105 (66%)95 (60%)9.90 (0.007*)
  Leu/Ser 45 (28%)63 (40%) 
  Leu/Leu 9 (6%)1 (1%) 

* Bonferroni corrected P value=0.035.

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