TABLE 1

FROM:

Synergistic Action of 5-HT_2A Antagonists and Selective Serotonin Reuptake Inhibitors in Neuropsychiatric Disorders

Gerard J Marek, Linda L Carpenter, Christopher J McDougle and Lawrence H Price

Table 1. In Vitro Receptor Potency of Risperidone, Olanzapine, and Mirtazapine (K _I, nM)

Receptor	Risperidonea	Olanzapinea	Mirtazapine	Mianserin
5-HT2A	0.15	1.48	16.4b	7.0c
1-Adrenergic	2.7	44	500b	34d
Dopamine D2	3.77	20	10000b	2100d
5-HT1D	3.9	150	5000e	372f
Histamine H1	5.2	0.087	0.14b	0.40d
2-Adrenergic	8.0	280	10e	73d
5-HT2C	32	4.1	12.9e	10f
5-HT1A	190	610	5000e	1148f
Muscarinic	34,000	36	667b	820d

^a  Richelson and Souder (2000) (human receptors).

^b  Richelson (2001) (human receptors).

^c  Wander et al (1986) (human receptors).

^d  Richelson and Nelson (1984) (human receptors).

^e  De Boer (1996) (animal receptors).

^f  Hoyer et al (1990) (animal receptors).