FIGURE 3
FROM:
Inhibition of 5-HT Neurotransmission Increases Clonidine Protective Effects on Naloxone-induced Conditioned Place Aversion in Morphine-dependent Rats
Stéphanie Caillé, Luis Stinus, Emilio F Espejo, Philippe De Deurwaerdère, Umberto Spampinato and George F Koob
BACK TO ARTICLEFigure 3.
8-OH-DPAT enhancement of clonidine effects on naloxone-induced conditioned place aversion. Place aversion conditioning was induced in morphine-dependent rats (subcutaneous implantation of 2 morphine pellets) by naloxone (15 
g/kg s.c.). Clonidine was given at 50 g/kg i.p. The following doses of 8-OH-DPAT were tested: 0, 5, 10, 25, 50 and 100 g/kg s.c. Clonidine and 8-OH-DPAT were injected 60 and 20 min, respectively, before each naloxone administration. Each column represents the difference in time spent in a given compartment during the test session minus the preconditioning score. Black bars, naloxone-paired compartment (D–D0); striped bars, saline-paired compartment (S–S0); white bars, neutral compartment (N–N0). Wilcoxon paired test D/D0: *p< 0.05; **p< 0.01.
