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| Original Article | |
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| Neuropsychopharmacology (2002) 27 792-799.10.1038/S0893-133X(02)00352-4 Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects Paolo Brambilla1,2,3 MD, Mark A Nicoletti1 MS, Keith Harenski1 BS, Roberto B Sassi1,7 MD, Alan G Mallinger1,4 MD, Ellen Frank1,5 Ph.D, David J Kupfer1,6 MD, Matcheri S Keshavan1 MD and Jair C Soares1 MD | |
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| 1Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 2Department of Psychiatry, IRCCS S. Matteo, University of Pavia School of Medicine, Pavia, Italy 3Advanced Biotechnology Center, University of Genova, Genova, Italy 4Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 5Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA 6Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA 7Department of Psychiatry, Institute of Psychiatry, University of Sao Paulo School of Medicine, Sao Paulo, Brazil Correspondence: Dr Jair C Soares, Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Tel.: (210) 567-5492; Fax: (210) 567-3759 E-mail: soares@uthscsa.edu | |
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| ABSTRACT | |
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| This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p> .05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial. Keywords: Neuroimaging; Magnetic resonance imaging; Mood disorders; Affective disorders; Bipolar disorder; Unipolar disorder; Depression | |
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