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| Neuropsychopharmacology (2002) 27 163-170.10.1038/S0893-133X(02)00288-9 Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex Douglas A Marsteller BS1,3, Madina R Gerasimov DDS1, Wynne K Schiffer BS1,3, Justin M Geiger BS1, Channing R Barnett BS1, Jana Schaich Borg BS1, Sabria Scott BS1, Jill Ceccarelli BS1, Nora D Volkow MD1,2,4, Patricia E Molina Ph.D5, David L Alexoff BSE1 and Stephen L Dewey Ph.D1,3 | |
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| 1Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 USA 2Medical Department, Brookhaven National Laboratory, Upton, NY 11973 USA 3Department of Neurobiology & Behavior, State University of New York, Stony Brook, NY, 11794 USA 4Department of Psychiatry, State University of New York, Stony Brook, NY, 11794 USA 5Department of Physiology, Louisiana State University, New Orleans, LA 70112 USA Correspondence: Madina R Gerasimov, DDS Chemistry Department, Brookhaven National Laboratory, Upton, New York, 11973, Tel.: (516) 344-4395; Fax: (516) 344-7902, E-mail: madina@bnl.gov | |
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| ABSTRACT | |
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| Although stress is an extensively investigated phenomenon, the effects of specific stressors on the pharmacologic activity of routinely administered drugs are less well characterized. We designed the present study to investigate the effect of handling stress on catecholaminergic responsivity following an acute methylphenidate (MP, Ritalin) challenge in the medial prefrontal cortex (mPFC). Norepinephrine (NE) and dopamine (DA) levels were simultaneously measured in 15-min samples of PFC dialysate using HPLC coupled with electrochemical detection. Sprague-Dawley rats were handled for 15 min, which produced an increase from basal extracellular DA and NE levels. Handling stress attenuates the DA response when administered 2 h prior to IP MP, whereas handling stress enhances the DA response when administered simultaneously with IG MP. These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge. Keywords: Handling stress; Methylphenidate; Medial prefrontal cortex; Norepinephrine; Dopamine; Microdialysis | |
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