|
|
 |
Neuropsychopharmacology (2002) 27 35-46.10.1038/S0893-133X(01)00427-4
Effects of Cocaine Self-administration on Striatal Dopamine Systems in Rhesus Monkeys: Initial and Chronic Exposure
Michael A Nader Ph.D, James B Daunais Ph.D, Tonya Moore MS, Susan H Nader BA, Rodney J Moore Ph.D, Hilary R Smith BA, David P Friedman Ph.D and Linda J Porrino Ph.D |
|
|
|
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157
Correspondence: Dr Michael A Nader, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083 Phone: (336) 713-7172, Fax: (336) 713-7168, E-mail: mnader@wfubmc.edu
|
|
|
|
ABSTRACT
|
|
The purpose of this study was to examine the time course of changes in dopamine D1- and D2-like receptor densities in monkeys self-administering cocaine. Experimentally naïve adult male rhesus monkeys (n = 22) were divided into a food reinforcement group (n = 6), in which responding was maintained by food presentation, or into four cocaine self-administration groups (n = 4/group), based on dose (0.03 or 0.3 mg/kg per injection) and duration of exposure (5 or ~100 sessions). After the last session, monkeys were euthanized, brains were removed, frozen, and coronal sections through the striatum, rostral to the anterior commissure, were processed for D1 ([3H]SCH23390) and D2 ([3H]raclopride) receptor autoradiography. Compared with controls, there was no effect of 5 days of cocaine self-administration on D1 and D2 receptors. In monkeys with extensive cocaine histories, D1 receptor densities were significantly increased relative to controls in some parts of the striatum, while D2 receptor densities were significantly decreased throughout the striatum. These findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion.
Keywords: Dopamine; D1 receptors; D2 receptors; Cocaine abuse; Striatum; Nucleus accumbens; Rhesus monkey |
|
| |
top  |
|
|
|
|
Send to a friend
Download PDF
Full Text
Next Article
Previous Article
Table of Contents