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Original Article |
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Neuropsychopharmacology (2001) 25 651-661.10.1038/S0893-133X(01)00281-0
Enhanced Reactivity and Vulnerability to Cocaine Following Methylphenidate Treatment in Adolescent Rats
Cindy L Brandon1 MA, Michela Marinelli2 Ph.D, Lorinda K Baker2 BA and Francis J White2 Ph.D |
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1Departments of Cell Biology and Anatomy, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL, USA
2Cellular and Molecular Pharmacology,, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL, USA
Correspondence: Dr Francis J White, Professor and Chair, Department of Cellular and Molecular Pharmacology, Finch University of Health Sciences/The Chicago Medical School, 3333 Green Bay Rd.,North Chicago, IL 60064. Tel.: 847-578-3270; Fax: 847-578-3268, e-mail: whitef@finchcms.edu
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ABSTRACT
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Treatment of attention deficit hyperactivity disorder with the psychostimulant drug methylphenidate (MP) has increased dramatically among schoolchildren. We tested whether repeated exposure to moderate doses of MP (5 and 10 mg/kg IP for 5 or 7 days) in adolescent rats increased reactivity to cocaine measured by motor responses (ambulations and rearing) to a cocaine challenge in adulthood. We later tested whether repeated exposure to a low dose of MP (2 mg/kg IP for 7 days) enhanced the psychomotor effects of cocaine, measured by different challenge doses (0-30 mg/kg) as well as to the reinforcing effects of cocaine, measured by self-administration of low-dose infusion (75  g/kg, IV). We found that exposure to moderate doses of MP enhanced psychomotor responses to cocaine but exposure to a low dose only increased cocaine self-administration. These results suggest that adolescent exposure to low doses of MP in rats may increase the incentive value of low reinforcers, thereby rendering adult rats more susceptible to cocaine self-administration.
Keywords: Attention deficit hyperactivity disorder; Self-administration; Sensitization; RitalinÒ; Substance abuse disorder; Addiction |
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