 |
 |
|
 |
|
|
|
 |
|
|
|
|||||||||||||||||
|
|||||||||||||||||
|
|||||||||||||||||
|
 |
|
|
Journal home |
|
|
| Current Issue |
| |
| Advance Online Publication |
| |
| Archive |
| |
|
Online sample issue FREE! |
|
|
|
Author index |
|
|
|
Keyword index |
|
|
|
|
|
|
|
|
|
Editorial Board |
|
|
|
Instructions for authors |
|
|
|
Aims and scope |
|
|
|
Indexed in |
|
|
|
Author queries |
|
|
|
Online Submission |
|
|
|
|
|
|
|
|
|
Subscription information |
|
|
|
Journal prices |
|
|
|
Order sample issue |
|
|
|
Purchase articles, reprints & permissions |
|
|
|
Advertising |
|
|
|
Contact NPG |
|
|
|
|
 |
|
|
|
| Original Article | |
| |
| |
| Neuropsychopharmacology (2001) 25 527-536.10.1038/S0893-133X(01)00246-9 Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor 'Knockout' Jeremiah J Clifford1,3 Ph.D, Anthony Kinsella4 MSc, Orna Tighe2 MSc, Marcelo Rubinstein5 Ph.D, David K Grandy6 Ph.D, Malcolm J Low7 MD, Ph.D, David T Croke2 Ph.D and John L Waddington1 Ph.D, DSc | |
| |
| |
| |
| 1Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland 2Department of Biochemistry, Royal College of Surgeons in Ireland, Dublin, Ireland 3Department of Biochemistry, Tralee General Hospital, Tralee, Ireland 4Department of Mathematics, Dublin Institute of Technology, Dublin, Ireland 5Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Universidad de Buenos Aires, Buenos Aires, Argentina 6Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR, USA 7Vollum Institute, Oregon Health Sciences University, Portland, OR, USA Correspondence: Dr John L Waddington, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland | |
|
|
|
|
|
|
| ABSTRACT | |
| |
| Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors ['knockouts'], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and 'knockouts'. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, 'naturalistic' conditions but not under 'phasic' challenge. Keywords: Dopamine D2 receptor; D2 'knockout'; Targeted gene deletion; Behavioural phenotype; Topographical assessment; Ethogram | |
|
|
top  |
|
|
|
 |
Article Links |  |
|
||
|
||
|
||
|
 Send to a friend |
|
|
 Download PDF |
|
|
 Full Text |
|
|
||
|
||
|
||
|
 Next Article |
|
|
 Previous Article |
|
|
 Table of Contents |
|
|
||
|
||
Privacy Policy