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Original Article |
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Neuropsychopharmacology (1999) 21 662-669.10.1038/sj.npp.1395390
Gamma-Hydroxybutyrate and Cocaine Administration Increases mRNA Expression of Dopamine D1 and D2 Receptors in Rat Brain
Catherine Schmidt-Mutter1,3 MD, Ph.D, Claude Muller1, Jean Zwiller2 Ph.D, Serge Gobaille1 and Michel Maitre1 MD, Ph.D |
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1LNMIC, Pascal, Strasbourg, France
2Centre de Neurochimie, Pascal, Strasbourg, France
3Department d'Anesthe´sie-Reanimation, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Correspondence: Dr Catherine Schmidt-Mutter, LNMIC, ER 2072 CNRS, 11 rue Humann, 67085 Strasbourg Cedex, France
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ABSTRACT
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The effects of acute and repeated gamma-hydroxybutyrate (GHB) and cocaine administration on D1 and D2 dopamine receptor mRNA expression were examined using in situ hybridization histochemistry in different rat brain structures rich in GHB receptors. Six hours after a single GHB administration (500 mg/kg IP), an increase in D1 and D2 mRNA expression was observed in almost all regions examined; whereas, acute cocaine injection (20 mg/kg IP) had no effect. Repeated exposure to GHB (500 mg/kg IP twice daily) for 10 days, followed by a 14-h withdrawal period, induced increasing effects on D1 and D2 dopamine receptor mRNA expression, similar to those caused by chronic treatment with cocaine (20 mg/kg IP once a day). These effects of GHB and cocaine on dopamine receptor mRNA expression could be a consequence, for both compounds, of the modulation of dopaminergic activity; thus, supporting the benefit of GHB in cocaine substitution therapy.
Keywords: GHB ( -hydroxybutyrate); Cocaine; D1 and D2 dopamine receptors mRNA; In situ hybridization; Rat brain |
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