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| Neuropsychopharmacology (1997) 16 298-310. Gender Differences in Brain Metabolic and Plasma Catecholamine Responses to Alpha2-Adrenoceptor Blockade Mark E Schmidt MD1, John A Matochik Ph.D5, David S Goldstein MD, Ph.D4, Jennifer L Schouten2, Alan J Zametkin MD3 and William Z Potter MD, Ph.D6 | |
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| 1From the Experimental Therapeutics Branch, National Institute of Mental Health 2The Section on Functional Brain Imaging Laboratory of Psychology and Psychopathology, National Institute of Mental Health 3The Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism (AJZ), National Institute of Mental Health 4The Clinical Neurochemistry Section, Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stoke, National Institutes of Health, Bethesda, Maryland 5The Brain Imaging Section, National Institute of Drug Abuse, Baltimore, Maryland 6The Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana. Correspondence: Mark E Schmidt, MD, Lilly Research Laboratories DC:0532, Lilly Corporate Center, Indianapolis, IN 46285. | |
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| ABSTRACT | |
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 2-Adrenergic receptors modulate the release of several neurotransmitters implicated in the treatment and pathophysiology of mood and anxiety disorders. Significant sex differences occur in the prevalence of both disorders. To test whether gender affects 2 function, the plasma catecholamine and brain metabolic responses to 2 blockade were measured in male and female volunteers. Ten female and thirteen male volunteers underwent [18F]-fluoro-deoxyglucose (FDG) positron emission tomography (PET) scans before and after infusion of idazoxan (200  g/kg). Measures of plasma catecholamines, blood pressure, and anxiety were obtained. Norepinephrine responses were larger in males. Women showed global increases in metabolism, whereas males had no global changes and some regional decreases in FDG uptake following idazoxan administration. The differences in norepinephrine increases are consistent with previously reported effects of gender on sympathetic activation. The PET data suggest gender differences in responses to 2-receptor blockade in brain as well.Keywords: Idazoxan; Alpha2-adrenoceptor antagonist; Sex characteristics; Positron emission tomography (PET); [18F]-fluoro-deoxyglucose (FDG); Imidazoline | |
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