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| Neuropsychopharmacology (1995) 12 73-86. Cerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls James F Leckman MD 1,2,4,5, Wayne K Goodman MD 7, George M Anderson Ph.d1,5, Mark A Riddle MD 8, Phillip B Chappell MD 1,5, Maureen T McSwiggan-Hardin MSN 9, Christopher J McDougle MD 1,2,6, Lawrence D Scahill MSN 1,5, Sharon I Ort MPH 1,5, David L Pauls Ph.d 1,3,5, Donald J Cohen MD 1,2,4,5 and Lawrence H Price MD 2,6 | |
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| 1Child Study Center, Yale University School of Medicine, New Heaven, Connecticut 2Department of Psychiatry, Yale University School of Medicine, New Heaven, Connecticut 3Department of Genetics, Yale University School of Medicine, New Heaven, Connecticut 4Department of Padiatrics, Yale University School of Medicine, New Heaven, Connecticut 5General Clinical Research Centers, Yale-New Haven Hospital, New Haven, Connecticut 6Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilites, Connecticut Mental Health Center, New Haven, Connecticut 7Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida 8Department of Psychiatry and Behavioral Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 9Department of Psychiatry, Medical College of Georgia, Augusta, Georgia Correspondence: James F Leckman, Child Study Center, 230S, Frontage Road, P.O. Box 207900, New Haven, CT 06520-7900 | |
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| ABSTRACT | |
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| To examine the role of noradrenergic, dopaminergic, and serotonergic mechanisms in the pathobiology of obsessive compulsive disorder (OCD) and Tourette's syndrome (TS), concentrations of tyrosine (TYR), norepinephrine (NE), 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), homovanillic acid (HVA), tryptophan (TRP), and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the lumbar cerebrospinal fluid (CSF) of 39 medication-free OCD patients, 33 medication-free TS patients, and 44 healthy volunteers. CSF TYR concentrations were reduced (p < .05) in the OCD patients compared to the healthy subjects. CSF NE in TS patients was 55% higher than in healthy controls (p < .001) and 35% higher than in OCD patients (p < .001). After covarying for height, CSF HVA levels were reduced (p <.05) in the OCD group compared to TS patients but not compared to the normal volunteers. No mean differences in CSF MHPG, TRP, and 5-HIAA were observed in this study across the three groups. The CSF NE data support the hypothesis that noradrenergic mechanisms are involved in the pathobiology of TS. Alterations in the balance of noradrenergic, dopaminergic, and serotonergic systems are likely involved in the pathobiology of OCD. Keywords: Obsessive compulsive disorder; Tourette's syndrome; CSF; Tyrosine; norepinephrine; 3-methoxy-4-hydroxyphenylethylene glycol; homovanillic acid; tryptophan; 5-hydroxyindoleacetic acid | |
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