Letter abstract
Nature Physics 5, 231 - 235 (2009)
Published online: 1 February 2009 | doi:10.1038/nphys1196
Subject Categories: Fluid dynamics | Electronics, photonics and device physics
Frequency-specific flow control in microfluidic circuits with passive elastomeric features
Daniel C. Leslie1,2, Christopher J. Easley2,5, Erkin Seker2, James M. Karlinsey2,5, Marcel Utz1,3, Matthew R. Begley1,3 & James P. Landers1,2,3,4
A fundamental challenge in the design of microfluidic devices lies in the need to control the transport of fluid according to complex patterns in space and time, and with sufficient accuracy. Although strategies based on externally actuated valves have enabled marked breakthroughs in chip-based analysis1, 2, 3, 4, 5, this requires significant off-chip hardware, such as vacuum pumps and switching solenoids, which strongly tethers such devices to laboratory environments6, 7, 8, 9, 10. Severing the microfluidic chip from this off-chip hardware would enable a new generation of devices that place the power of microfluidics in a broader range of disciplines. For example, complete on-chip flow control would empower highly portable microfluidic tools for diagnostics, forensics, environmental analysis and food safety, and be particularly useful in field settings where infrastructure is limited. Here, we demonstrate an elegantly simple strategy for flow control: fluidic networks with embedded deformable features are shown to transport fluid selectively in response to the frequency of a time-modulated pressure source. Distinct fluidic flow patterns are activated through the dynamic control of a single pressure input, akin to the analog responses of passive electrical circuits composed of resistors, capacitors and diodes.
- Center For Microsystems For The Life Sciences,
- Department of Chemistry,
- Department of Mechanical and Aerospace Engineering,
- Department of Pathology, University of Virginia, Charlottesville, Virginia 22904, USA
- Present addresses: Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (C.J.E.); Department of Chemistry, Penn State Berks, Reading, Pennsylvania 19610, USA (J.M.K.)
Correspondence to: Matthew R. Begley1,3 e-mail: begley@Virginia.EDU
Correspondence to: James P. Landers1,2,3,4 e-mail: jpl5e@Virginia.EDU
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