Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Super-resolution imaging

Beyond the realm of fluorescence

Nature Photonics volume 7, pages 426–428 (2013)Cite this article

Subjects

Using a pump–probe technique, scientists have experimentally demonstrated a nonlinear imaging scheme that permits the super-resolution imaging of nonfluorescent samples, making it promising for use with unstained specimens.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: An STED-like scheme for realizing super-resolution transient-absorption imaging.

References

  1. Wilson, T. & Sheppard, C. Theory and Practice of Scanning Optical Microscopy 151 (Academic, 1984).

    Google Scholar 

  2. Bouwhuis, G. & Spruit, J. H. M. Appl. Opt. 29, 3766–3768 (1990).

    Article  ADS  Google Scholar 

  3. Hell, S. W. & Wichmann, J. Opt. Lett. 19, 780–782 (1994).

    Article  ADS  Google Scholar 

  4. Heintzmann, R., Jovin, T. M. & Cremer, C. J. Opt. Soc. Am. A 19, 1599–1609 (2002).

    Article  ADS  Google Scholar 

  5. Hennig, S., van de Linde, S., Heilemann, M. & Sauer, M. Nano Lett. 9, 2466–2470 (2009).

    Article  ADS  Google Scholar 

  6. Hajek, K. M., Littleton, B., Turk, D., McIntyre, T. J. & Rubinsztein-Dunlop, H. Opt. Express 18, 19263–19272 (2010).

    Article  ADS  Google Scholar 

  7. Beeker, W. P. et al. Phys. Rev. A 81, 012507 (2010).

    Article  ADS  Google Scholar 

  8. Lee, H. et al. in Proc. SPIE 8597, paper 85970P (2013).

    Google Scholar 

  9. Wang, P. et al. Nature Photon. 7, 449–453 (2013).

    Article  ADS  Google Scholar 

  10. Silien, C., Liu, N., Hendaoui, N., Tofail, S. A. M. & Peremans, A. Opt. Express 20, 29694–29704 (2012).

    Article  ADS  Google Scholar 

  11. Heintzmann, R. et al. Micron 34, 293–300 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Germany and the Randal Division, Rainer Heintzmann is at the Institute of Photonic Technology, Albert-Einstein Str. 9, 07745 Jena, Germany, the Institute of Physical Chemistry, Abbe Center of Photonics, Friedrich-Schiller University Jena, 07743 Jena, King's College London, SE1 1UL, London, U.K.,

    Rainer Heintzmann

Authors
  1. Rainer Heintzmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rainer Heintzmann.

Ethics declarations

Competing interests

The author holds a patent for nonlinear structured illumination.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heintzmann, R. Beyond the realm of fluorescence. Nature Photon 7, 426–428 (2013). https://doi.org/10.1038/nphoton.2013.117

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nphoton.2013.117

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing