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Operando transmission electron microscopy imaging reveals that modifying interlayer rotations alters both the spatial arrangement and switching dynamics of polar domains in artificially stacked trilayers of WSe2.
Understanding how cells process nanoparticles is crucial to improve nanomedicine efficacy. Here a genome-wide screening is used to discover proteins that are involved in silica nanoparticle accumulation by cells and shows that different apolipoprotein receptors and proteoglycans mediate their internalization.
Tumour cell behaviour is an underdeveloped target for cancer intervention. Here the authors report on a spatiotemporal interaction between tumour cells and osteoclasts in initial bone metastases and propose a behaviour-targeting therapy with an in situ physical killing strategy.
The spacing of ligands presented to cells can have a huge impact on cellular responses. DNA origami is used to block structures to control the distribution of Toll-like receptor ligands and optimize presentation in the activation of dendritic cells in cancer immunotherapy.
There is interest in STING for immunotherapy, but it suffers from adverse proinflammatory effects. Here, the authors report on a non-membrane-associated polymeric universal STING mimic which triggers pathways involved in tumour control over proinflammatory pathways, demonstrating application in vivo.
The characterization and tuning of free radicals at the single molecule level is a challenging endeavour. Here electrical conductance measurements of a single molecule sandwiched between nanogapped graphene electrodes via covalent amide bonds reveal the conversion between closed-shell and open-shell form with temperature, electric and magnetic field in real time.
Tellurite molybdenum quaternary oxides, a family of van der Waals materials, show slow group velocity and long lifetimes with promising implications for tunable low-loss anisotropic polaritonics.
In contrast to textbook expectations, experimental findings show that, in certain situations, like-charged particles may either repel or attract each other depending on the sign of their charge and on the solvent.
By confining and concentrating light in a nanometric volume at the apex of a metallic tip, sub-molecule-scale control of a basic photochemical reaction — phototautomerization — is now shown to be possible. Applicable to other photo-induced reactions, this technique signals a new strategy for the synthesis of complex molecules on surfaces.
A process that leverages capillary interactions between oligomers in an elastomeric polydimethylsiloxane substrate and deposited Ga enables the formation of Ga nanodroplets with nanoscale gaps in a single step. Gap-plasmon resonances excited within the nanogaps give rise to structural colours that can be tuned by changing the oligomer content in the substrate or by mechanical stretching.
Weak laser light confined at the apex of a scanning tunnelling microscope tip can drive the tautomerization of a free-base phthalocyanine with atomic-scale precision. The combination of tip-enhanced photoluminescence spectroscopy and hyperspectral mapping paired with theoretical modelling then unravel an excited-state mediated reaction.
Integrating droplet-based microfluidics with a modular DNA circuit, here the authors report on monitoring the amplification reaction from single enzyme molecules in real time, revealing the distribution of activity among the catalyst population and alternative inactivation pathways under various stresses.
Exploiting capillary interactions of oligomers in polydimethylsiloxane and Ga allows single-step formation of closely spaced Ga nanodroplets in which gap plasmon resonances lead to mechanoresponsive structural colours, bypassing multiple chemical or lithographic steps.