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Robotics and machine learning are combined to predict and prepare a variety of nanocomposite materials with properties mimicking those of various types of plastics, starting from natural building blocks.
A genetically engineered variant of the stimulator of interferon genes (STING) protein is delivered to cancer cells, showing potential for clinical impact.
A distance-based mapping strategy using single-molecule fluorescence resonance energy transfer via DNA eXchange (FRET X) enables full-length fingerprinting of intact protein sequences.
The performance of three-terminal molecular transistors is enhanced through the harnessing of quantum interference in the edges of graphene electrodes.
An experimental demonstration of how destructive quantum interference effects can increase the performance of single-molecule field-effect transistors to reach levels similar to those of nanoelectronic transistors.
Operando transmission electron microscopy imaging reveals that modifying interlayer rotations alters both the spatial arrangement and switching dynamics of polar domains in artificially stacked trilayers of WSe2.
Understanding how cells process nanoparticles is crucial to improve nanomedicine efficacy. Here a genome-wide screening is used to discover proteins that are involved in silica nanoparticle accumulation by cells and shows that different apolipoprotein receptors and proteoglycans mediate their internalization.
Tumour cell behaviour is an underdeveloped target for cancer intervention. Here the authors report on a spatiotemporal interaction between tumour cells and osteoclasts in initial bone metastases and propose a behaviour-targeting therapy with an in situ physical killing strategy.
The spacing of ligands presented to cells can have a huge impact on cellular responses. DNA origami is used to block structures to control the distribution of Toll-like receptor ligands and optimize presentation in the activation of dendritic cells in cancer immunotherapy.
There is interest in STING for immunotherapy, but it suffers from adverse proinflammatory effects. Here, the authors report on a non-membrane-associated polymeric universal STING mimic which triggers pathways involved in tumour control over proinflammatory pathways, demonstrating application in vivo.
The characterization and tuning of free radicals at the single molecule level is a challenging endeavour. Here electrical conductance measurements of a single molecule sandwiched between nanogapped graphene electrodes via covalent amide bonds reveal the conversion between closed-shell and open-shell form with temperature, electric and magnetic field in real time.
Tellurite molybdenum quaternary oxides, a family of van der Waals materials, show slow group velocity and long lifetimes with promising implications for tunable low-loss anisotropic polaritonics.