Abstract
A major challenge in molecular electronics is to attach electrodes to single molecules in a reproducible manner to make molecular junctions that can be operated as transistors. Several attempts have been made to attach electrodes to proteins, but these devices have been unstable. Here, we show that self-assembly can be used to fabricate, in a highly reproducible manner, molecular junctions in which an antibody molecule (immunoglobulin G) binds to two gold nanoparticles, which in turn are connected to source and drain electrodes. We also demonstrate effective gating of the devices with an applied voltage, and show that the charge transport characteristics of these protein transistors are caused by conformational changes in the antibody. Moreover, by attaching CdSe quantum dots to the antibody, we show that the protein transistor can also be gated by an applied optical field. This approach offers a versatile platform for investigations of single-molecule-based biological functions and might also lead to the large-scale manufacture of integrated bioelectronic circuits.
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Change history
02 March 2012
In the version of this Article originally published, the address of the first affiliation was incorrect; the correct address should have read 'Biomedical Electronics Translational Research Center, National Chiao Tung University, 1001 University Road, Hsinchu, Taiwan, ROC'. This has now been corrected in the HTML and PDF versions.
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Acknowledgements
This work was supported by the ‘Aim for the Top University Plan’ of National Chiao Tung University and the Ministry of Education, Taiwan, ROC. The authors also acknowledge funding support from the Air Force Office of Scientific Research (AFOSR, FA2386-11-1-4094).
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Y.S.C. and G.S.H. are responsible for the study concept and design. G.S.H. and M.Y.H. prepared the manuscript. Y.S.C. and M.Y.H. carried out the experiments and performed the data analysis.
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Chen, YS., Hong, MY. & Huang, G. A protein transistor made of an antibody molecule and two gold nanoparticles. Nature Nanotech 7, 197–203 (2012). https://doi.org/10.1038/nnano.2012.7
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DOI: https://doi.org/10.1038/nnano.2012.7
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