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Volume 7 Issue 2, February 2012

Nanopore-based sensors are being developed for possible applications in DNA sequencing. These sensors normally work by recording the ionic current through the nanopore: in particular they record the small changes in the current caused by the passage of biomolecules through the nanopore. However, DNA molecules pass through nanopores extremely quickly and the bandwidth of existing read-out systems is not high enough to cope with the resulting signal. Now Charles Lieber and co-workers have combined solid-state nanopores with nanowire field-effect transistors to create a high bandwidth read-out system in which the presence of a DNA molecule changes the electric potential near the nanopore, which in turn modulates the conductivity of the nanowire. The small rectangle at the centre of this photograph is a silicon nitride membrane (about 90 μm across) that contains the nanowire-nanopore sensors. The white lines are metal electrodes.

Letter p119; News & Views p81

IMAGE: PING XIE, HARVARD UNIVERSITY

COVER DESIGN: ALEX WING

Correspondence

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Research Highlights

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News & Views

  • Sensors that combine solid-state nanopores and nanowire field-effect transistors can be used to detect single DNA molecules quickly and with high sensitivity.

    • Dario Anselmetti
    News & Views
  • The thermal conductivity of pairs of boron nanoribbons can be switched between high and low values by wetting the interface between the nanoribbons with various solutions.

    • Chris Dames
    News & Views
  • Circularly polarized light can isolate surface states from bulk states in topological insulators, allowing their unique properties to be probed.

    • Judy J. Cha
    • Yi Cui
    News & Views
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Letter

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