Complex artificial networks of genes have been designed that can sense a number of input signals in a user-defined logic to produce predictable output behaviours in mammalian cells.
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Chalancon, G., Babu, M. Scaling up synthetic gene circuits. Nature Nanotech 5, 631–633 (2010). https://doi.org/10.1038/nnano.2010.178
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DOI: https://doi.org/10.1038/nnano.2010.178