Article abstract

Nature Nanotechnology 5, 61 - 66 (2010)
Published online: 8 November 2009 | doi:10.1038/nnano.2009.311

Subject Categories: Carbon nanotubes and fullerenes | Molecular self-assembly

Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates

Hareem T. Maune1,2, Si-ping Han1,2, Robert D. Barish1,2, Marc Bockrath1, William A. Goddard III1, Paul W. K. Rothemund1 & Erik Winfree1

A central challenge in nanotechnology is the parallel fabrication of complex geometries for nanodevices. Here we report a general method for arranging single-walled carbon nanotubes in two dimensions using DNA origami—a technique in which a long single strand of DNA is folded into a predetermined shape. We synthesize rectangular origami templates (~75 nm × 95 nm) that display two lines of single-stranded DNA ‘hooks’ in a cross pattern with ~6 nm resolution. The perpendicular lines of hooks serve as sequence-specific binding sites for two types of nanotubes, each functionalized non-covalently with a distinct DNA linker molecule. The hook-binding domain of each linker is protected to ensure efficient hybridization. When origami templates and DNA-functionalized nanotubes are mixed, strand displacement-mediated deprotection and binding aligns the nanotubes into cross-junctions. Of several cross-junctions synthesized by this method, one demonstrated stable field-effect transistor-like behaviour. In such organizations of electronic components, DNA origami serves as a programmable nanobreadboard; thus, DNA origami may allow the rapid prototyping of complex nanotube-based structures.

  1. California Institute of Technology, Pasadena, California 91125, USA
  2. These authors contributed equally to this work

Correspondence to: Si-ping Han1,2 e-mail:


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