Letter abstract
Nature Nanotechnology 4, 557 - 561 (2009)
Published online: 16 August 2009 | doi:10.1038/nnano.2009.220
Subject Categories: Molecular self-assembly | Surface patterning and imaging
Placement and orientation of individual DNA shapes on lithographically patterned surfaces
Ryan J. Kershner1,4, Luisa D. Bozano1, Christine M. Micheel1,4, Albert M. Hung1,4, Ann R. Fornof1,4, Jennifer N. Cha1,4, Charles T. Rettner1, Marco Bersani1,4, Jane Frommer1, Paul W. K. Rothemund2 & Gregory M. Wallraff1
Abstract
Artificial DNA nanostructures1, 2 show promise for the organization of functional materials3, 4 to create nanoelectronic5 or nano-optical devices. DNA origami, in which a long single strand of DNA is folded into a shape using shorter 'staple strands'6, can display 6-nm-resolution patterns of binding sites, in principle allowing complex arrangements of carbon nanotubes, silicon nanowires, or quantum dots. However, DNA origami are synthesized in solution and uncontrolled deposition results in random arrangements; this makes it difficult to measure the properties of attached nanodevices or to integrate them with conventionally fabricated microcircuitry. Here we describe the use of electron-beam lithography and dry oxidative etching to create DNA origami-shaped binding sites on technologically useful materials, such as SiO2 and diamond-like carbon. In buffer with 
100 mM MgCl2, DNA origami bind with high selectivity and good orientation: 70–95% of sites have individual origami aligned with an angular dispersion (
1 s.d.) as low as 10° (on diamond-like carbon) or 20° (on SiO2).
- IBM Almaden Research Center, San Jose, California 95120, USA
- Department of Bioengineering, Computer Science, and Computation & Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
- Present address: University of Wisconsin, Madison, Wisconsin 53706, USA (R.J.K); The National Academies, Washington DC 20001, USA (C.M.M.); Department of Nanoengineering, University of California, San Diego, California 92093, USA (A.M.H., J.N.C.); Center for Nanoscience, Ludwig-Maximilians Universität, 80799 Munich, Germany (A.R.F.); Dipartimento di Fisica, Università di Padova, I-35131 Padova, Italy (M.B.)
Correspondence to: Paul W. K. Rothemund2 e-mail: pwkr@dna.caltech.edu
Correspondence to: Gregory M. Wallraff1 e-mail: gmwall@almaden.ibm.com
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