Progress Article abstract
Nature Nanotechnology 4, 411 - 414 (2009)
Published online: 28 June 2009 | doi:10.1038/nnano.2009.175
Subject Categories: Nanomedicine | Environmental, health and safety issues
Evaluation of nanoparticle immunotoxicity
Marina A. Dobrovolskaia1, Dori R. Germolec2 & James L. Weaver3
Abstract
The pharmaceutical industry is developing increasing numbers of drugs and diagnostics based on nanoparticles, and evaluating the immune response to these diverse formulations has become a challenge for scientists and regulatory agencies alike. An international panel of scientists and representatives from various agencies and companies reviewed the imitations of current tests at a workshop held at the National Cancer Institute in Frederick, Maryland. This article outlines practical strategies for identifying and controlling interferences in common evaluation methods and the implications for regulation.
- Nanotechnology Characterization Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA
- Toxicology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
- Division of Applied Pharmacology Research, CDER, US FDA, Silver Spring, Maryland 20993, USA.
Correspondence to: Marina A. Dobrovolskaia1 e-mail: marina@mail.nih.gov
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