Letter abstract
Nature Nanotechnology 4, 245 - 248 (2009)
Published online: 15 February 2009 | doi:10.1038/nnano.2009.5
Subject Categories: Molecular self-assembly | Surface patterning and imaging
Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate
Hongzhou Gu1, Jie Chao2, Shou-Jun Xiao2 & Nadrian C. Seeman1
Abstract
The aim of nanotechnology is to put specific atomic and molecular species where we want them, when we want them there. Achieving such dynamic and functional control could lead to programmable chemical synthesis and nanoscale systems that are responsive to their environments. Structural DNA nanotechnology offers a powerful route to this goal by combining stable branched DNA motifs1 with cohesive ends to produce programmed nanomechanical devices2 and fixed3, 4, 5 or modified6, 7 patterned lattices. Here, we demonstrate a dynamic form of patterning8 in which a pattern component is captured between two independently programmed DNA devices. A simple and robust error-correction protocol has been developed that yields programmed targets in all cases. This capture system can lead to dynamic control either on patterns or on programmed elements; this capability enables computation or a change of structural state as a function of information in the surroundings of the system.
- Department of Chemistry, New York University, New York, New York 10003, USA
- State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, China
Correspondence to: Nadrian C. Seeman1 ned.seeman@nyu.edu
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