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Nature Nanotechnology 4, 72–73 (1 February 2009) | doi:10.1038/nnano.2009.036

Applicability of AFM in cancer detection

Sarah E. Cross , Yu-Sheng Jin , Jianyu Rao & James K. Gimzewski

Cross et al. reply — Taking measurements on more cells is no doubt a necessity. However, mapping the cell by taking multiple indentations at different locations on the cell introduces variations, because as one goes off-centre and closer to the cell edge, the contact area of the tip changes and the Hertz model becomes less accurate (Fig.