Letter abstract


Nature Nanotechnology 3, 548 - 551 (2008)
Published online: 11 July 2008 | doi:10.1038/nnano.2008.189

Subject Categories: Molecular self-assembly | Nanoparticles | Nanosensors and other devices

Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles

Duncan Graham1, David G. Thompson1, W. Ewen Smith1 & Karen Faulds1


Enhanced Raman scattering from metal surfaces has been investigated for over 30 years1. Silver surfaces are known to produce a large effect, and this can be maximized by producing a roughened surface, which can be achieved by the aggregation of silver nanoparticles2, 3, 4. However, an approach to control this aggregation, in particular through the interaction of biological molecules such as DNA, has not been reported. Here we show the selective turning on of the surface enhanced resonance Raman scattering5 effect on dye-coded, DNA-functionalized, silver nanoparticles through a target-dependent, sequence-specific DNA hybridization assembly that exploits the electromagnetic enhancement mechanism for the scattering. Dye-coded nanoparticles that do not undergo hybridization experience no enhancement and hence do not give surface enhanced resonance Raman scattering. This is due to the massive difference in enhancement from nanoparticle assemblies compared with individual nanoparticles. The electromagnetic enhancement is the dominant effect and, coupled with an understanding of the surface chemistry, allows surface enhanced resonance Raman scattering nanosensors to be designed based on a natural biological recognition process.

Top
  1. Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK

Correspondence to: Duncan Graham1 e-mail: duncan.graham@strath.ac.uk



MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Finding enzymatic gold on silver surfaces

Nature Biotechnology News and Views (01 Sep 2004)

Spectroscopy Expanding versatility

Nature News and Views (18 Mar 2010)

See all 5 matches for News And Views