Focus
Nanopores
Nanopore-based sensors allow DNA and other biomolecules to be analysed with subnanometre resolution and without the need for labels or amplification. Researchers are working on naturally occurring biological nanopores, solid-state nanopores and hybrids of the two, along with a variety of new readout methods. The ultimate goal of this research is to be able to rapidly and reliably sequence the human genome for under $1,000. This web focus brings together all the articles that Nature Nanotechnology has published on various aspects of nanopores and their applications.
Introduction
Review article:
Nanopore sensors for nucleic acid analysis
Bala Murali Venkatesan & Rashid Bashir
doi:10.1038/nnano.2011.129
Abstract - Nanopore sensors for nucleic acid analysis | Full text - Nanopore sensors for nucleic acid analysis | PDF (2,120 KB) - Nanopore sensors for nucleic acid analysis
Review article:
Solid-state nanopores
Cees Dekker
doi:10.1038/nnano.2007.27
Abstract - Solid-state nanopores | Full text - Solid-state nanopores | PDF (870 KB) - Solid-state nanopores
Biological nanopores
Article:
Nanopore-based detection of circulating microRNAs in lung cancer patients
Yong Wang, Dali Zheng, Qiulin Tan, Michael X. Wang & Li-Qun Gu
doi:10.1038/nnano.2011.147
Abstract - Nanopore-based detection of circulating microRNAs in lung cancer patients | Full text - Nanopore-based detection of circulating microRNAs in lung cancer patients | PDF (3,637 KB) - Nanopore-based detection of circulating microRNAs in lung cancer patients | Supplementary information
Article:
Continuous base identification for single-molecule nanopore DNA sequencing
James Clarke, Hai-Chen Wu, Lakmal Jayasinghe, Alpesh Patel, Stuart Reid & Hagan Bayley
doi:10.1038/nnano.2009.12
Abstract - Continuous base identification for single-molecule nanopore DNA sequencing | Full text - Continuous base identification for single-molecule nanopore DNA sequencing | PDF (2,757 KB) - Continuous base identification for single-molecule nanopore DNA sequencing | Supplementary information
Article:
Translocation of double-stranded DNA through membrane-adapted phi29 motor protein nanopores
David Wendell, Peng Jing, Jia Geng, Varuni Subramaniam, Tae Jin Lee, Carlo Montemagno & Peixuan Guo
doi:10.1038/nnano.2009.259
Abstract - Translocation of double-stranded DNA through membrane-adapted phi29 motor protein nanopores | Full text - Translocation of double-stranded DNA through membrane-adapted phi29 motor protein nanopores | PDF (1,291 KB) - Translocation of double-stranded DNA through membrane-adapted phi29 motor protein nanopores | Supplementary information
Article:
Replication of individual DNA molecules under electronic control using a protein nanopore
Felix Olasagasti, Kate R. Lieberman, Seico Benner, Gerald M. Cherf, Joseph M. Dahl, David W. Deamer & Mark Akeson
doi:10.1038/nnano.2010.177
Abstract - Replication of individual DNA molecules under electronic control using a protein nanopore | Full text - Replication of individual DNA molecules under electronic control using a protein nanopore | PDF (13,930 KB) - Replication of individual DNA molecules under electronic control using a protein nanopore | Supplementary information
Letter:
Sequence-specific detection of individual DNA polymerase complexes in real-time using a nanopore
Seico Benner, Roger J. A. Chen, Noah A. Wilson, Robin Abu-Shumays, Nicholas Hurt, Kate R. Lieberman, David W. Deamer, William B. Dunbar & Mark Akeson
doi:10.1038/nnano.2007.344
Abstract - Sequence-specific detection of individual DNA polymerase complexes in real-time using a nanopore | Full text - Sequence-specific detection of individual DNA polymerase complexes in real-time using a nanopore | PDF (3,261 KB) - Sequence-specific detection of individual DNA polymerase complexes in real-time using a nanopore | Supplementary information
Solid-state and hybrid nanopores
Article:
Stochastic sensing of proteins with receptor-modified solid-state nanopores
Ruoshan Wei, Volker Gatterdam, Ralph Wieneke, Robert Tampé & Ulrich Rant
doi:10.1038/nnano.2012.24
Abstract - Stochastic sensing of proteins with receptor-modified solid-state nanopores |
Full text - Stochastic sensing of proteins with receptor-modified solid-state nanopores |
PDF (1,707 KB) - Stochastic sensing of proteins with receptor-modified solid-state nanopores |
Supplementary information
See also: News and Views by Gu et al.
Letter:
Electric-field-induced wetting and dewetting in single hydrophobic nanopores
Matthew R. Powell, Leah Cleary, Matthew Davenport, Kenneth J. Shea & Zuzanna S. Siwy
doi:10.1038/nnano.2011.189
Abstract - Electric-field-induced wetting and dewetting in single hydrophobic nanopores |
Full text - Electric-field-induced wetting and dewetting in single hydrophobic nanopores |
PDF (679 KB) - Electric-field-induced wetting and dewetting in single hydrophobic nanopores |
Supplementary information
See also: News and Views by Rant
Article:
Controlling protein translocation through nanopores with bio-inspired fluid walls
Erik C. Yusko, Jay M. Johnson, Sheereen Majd, Panchika Prangkio, Ryan C. Rollings, Jiali Li, Jerry Yang & Michael Mayer
doi:10.1038/nnano.2011.12
Abstract - Controlling protein translocation through nanopores with bio-inspired fluid walls |
Full text - Controlling protein translocation through nanopores with bio-inspired fluid walls |
PDF (3,975 KB) - Controlling protein translocation through nanopores with bio-inspired fluid walls |
Supplementary information
See also: News and Views by Albrecht
Letter:
Single-molecule transport across an individual biomimetic nuclear pore complex
Stefan W. Kowalczyk, Larisa Kapinos, Timothy R. Blosser, Tomás Magalhäes, Pauline van Nies, Roderick Y. H. Lim & Cees Dekker
doi:10.1038/nnano.2011.88
Abstract - Single-molecule transport across an individual biomimetic nuclear pore complex |
Full text - Single-molecule transport across an individual biomimetic nuclear pore complex |
PDF (2,688 KB) - Single-molecule transport across an individual biomimetic nuclear pore complex |
Supplementary information
See also: News and Views by Jovanovic-Talisman and Zilman
Letter:
Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores
Adam R. Hall, Andrew Scott, Dvir Rotem, Kunal K. Mehta, Hagan Bayley & Cees Dekker
doi:10.1038/nnano.2010.237
Abstract - Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores | Full text - Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores | PDF (684 KB) - Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores | Supplementary information
Article:
Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors
Meni Wanunu, Tali Dadosh, Vishva Ray, Jingmin Jin, Larry McReynolds & Marija Drndić
doi:10.1038/nnano.2010.202
Abstract - Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors | Full text - Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors | PDF (1,684 KB) - Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors | Supplementary information
News & Views:
Nanopores: Graphene opens up to DNA
Zuzanna Siwy and Matthew Davenport
doi:10.1038/nnano.2010.198
Abstract - Nanopores: Graphene opens up to DNA | Full text - Nanopores: Graphene opens up to DNA | PDF (268 KB) - Nanopores: Graphene opens up to DNA
Article:
Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient
Meni Wanunu, Will Morrison, Yitzhak Rabin, Alexander Y. Grosberg & Amit Meller
doi:10.1038/nnano.2009.379
Abstract - Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient | Full text - Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient | PDF (2,306 KB) - Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient | Supplementary information
Letter:
Recapturing and trapping single molecules with a solid-state nanopore
Marc Gershow & J. A. Golovchenko
doi:10.1038/nnano.2007.381
Abstract - Recapturing and trapping single molecules with a solid-state nanopore |
Full text - Recapturing and trapping single molecules with a solid-state nanopore |
PDF (326 KB) - Recapturing and trapping single molecules with a solid-state nanopore |
Supplementary information
See also: News and Views by Stein
Article:
Solid-state nanopore channels with DNA selectivity
Samir M. Iqbal, Demir Akin & Rashid Bashir
doi:10.1038/nnano.2007.78
Abstract - Solid-state nanopore channels with DNA selectivity | Full text - Solid-state nanopore channels with DNA selectivity | PDF (1,369 KB) - Solid-state nanopore channels with DNA selectivity | Supplementary information
Readout technologies
Letter:
Local electrical potential detection of DNA by nanowire–nanopore sensors
Ping Xie, Qihua Xiong, Ying Fang, Quan Qing & Charles M. Lieber
doi:10.1038/nnano.2011.217
Abstract - Local electrical potential detection of DNA by nanowire–nanopore sensors |
Full text - Local electrical potential detection of DNA by nanowire–nanopore sensors |
PDF (3,440 KB) - Local electrical potential detection of DNA by nanowire–nanopore sensors |
Supplementary information
See also: News and Views by Anselmetti
Letter:
Fast DNA sequencing with a graphene-based nanochannel device
Seung Kyu Min, Woo Youn Kim, Yeonchoo Cho & Kwang S. Kim
doi:10.1038/nnano.2010.283
Abstract - Fast DNA sequencing with a graphene-based nanochannel device | Full text - Fast DNA sequencing with a graphene-based nanochannel device | PDF (1,639 KB) - Fast DNA sequencing with a graphene-based nanochannel device | Supplementary information
Letter:
Identifying single bases in a DNA oligomer with electron tunnelling
Shuo Huang, Jin He, Shuai Chang, Peiming Zhang, Feng Liang, Shengqin Li, Michael Tuchband, Alexander Fuhrmann, Robert Ros & Stuart Lindsay
doi:10.1038/nnano.2010.213
Abstract - Identifying single bases in a DNA oligomer with electron tunnelling |
Full text - Identifying single bases in a DNA oligomer with electron tunnelling |
PDF (1,588 KB) - Identifying single bases in a DNA oligomer with electron tunnelling |
Supplementary information
See also: News and Views by Di Ventra
Letter:
Identifying single nucleotides by tunnelling current
Makusu Tsutsui, Masateru Taniguchi, Kazumichi Yokota & Tomoji Kawai
doi:10.1038/nnano.2010.42
Abstract - Identifying single nucleotides by tunnelling current |
Full text - Identifying single nucleotides by tunnelling current |
PDF (1,180 KB) - Identifying single nucleotides by tunnelling current |
Supplementary information
See also: News and Views by Thundat
News & Views:
Biosensors: Making nanopores from nanotubes
Zuzanna Siwy and Matthew Davenport
doi:10.1038/nnano.2010.33
Abstract - Biosensors: Making nanopores from nanotubes | Full text - Biosensors: Making nanopores from nanotubes | PDF (196 KB) - Biosensors: Making nanopores from nanotubes
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