Focus
DNA nanotechnology
The ability of DNA to self–assemble into a variety of nanostructures and nanomachines is highlighted in a growing number of papers in Nature Nanotechnology. The appeal of DNA to nanoscientists is threefold: first, it is a natural nanoscale material; second, a large number of techniques for studying DNA are already available; and third, its ability to carry information can be exploited in the self–assembly process. DNA is also increasingly being used to organize other nanomaterials, and the related field of RNA nanotechnology is beginning to emerge. All this can be seen in the articles below.
Introduction
Review:
Challenges and opportunities for structural DNA nanotechnology
Andre V. Pinheiro, Dongran Han, William M. Shih & Hao Yan
doi:10.1038/nnano.2011.187
Abstract - Challenges and opportunities for structural DNA nanotechnology | Full text - Challenges and opportunities for structural DNA nanotechnology | PDF (1,904 KB) - Challenges and opportunities for structural DNA nanotechnology
Editorial:
The unnatural order of things
doi:10.1038/nnano.2009.60
Abstract - The unnatural order of things | Full text - The unnatural order of things | PDF (99 KB) - The unnatural order of things
One-, two- and three-dimensional nanostructures
Letter:
Placement and orientation of individual DNA shapes on lithographically patterned surfaces
Ryan J. Kershner, Luisa D. Bozano, Christine M. Micheel, Albert M. Hung, Ann R. Fornof, Jennifer N. Cha, Charles T. Rettner, Marco Bersani, Jane Frommer, Paul W. K. Rothemund & Gregory M. Wallraff
doi:10.1038/nnano.2009.220
Abstract - Placement and orientation of individual DNA shapes on lithographically patterned surfaces | Full text - Placement and orientation of individual DNA shapes on lithographically patterned surfaces | PDF (766 KB) - Placement and orientation of individual DNA shapes on lithographically patterned surfaces | Supplementary information
Letter:
Reconfigurable, braced, three–dimensional DNA nanostructures
Russell P. Goodman, Mike Heilemann, Sören Doose, Christoph M. Erben, Achillefs N. Kapanidis & Andrew J. Turberfield
doi:10.1038/nnano.2008.3
Abstract - Reconfigurable, braced, three–dimensional DNA nanostructures |
Full text - Reconfigurable, braced, three–dimensional DNA nanostructures |
PDF (302 KB) - Reconfigurable, braced, three–dimensional DNA nanostructures |
Supplementary information
See also: News and Views by Mao
Letter:
Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate
Hongzhou Gu, Jie Chao, Shou–Jun Xiao & Nadrian C. Seeman
doi:10.1038/nnano.2009.5
Abstract - Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate | Full text - Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate | PDF (669 KB) - Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate | Supplementary information
Letter:
Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character
Faisal A. Aldaye, Pik Kwan Lo, Pierre Karam, Christopher K. McLaughlin, Gonzalo Cosa & Hanadi F. Sleiman
doi:10.1038/nnano.2009.72
Abstract - Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character |
Full text - Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character |
PDF (764 KB) - Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character |
Supplementary information
See also: News and Views by Grainger
Letter:
Self-assembly of three-dimensional prestressed tensegrity structures from DNA
Tim Liedl, Björn Högberg, Jessica Tytell, Donald E. Ingber & William M. Shih
doi:10.1038/nnano.2010.107
Abstract - Self-assembly of three-dimensional prestressed tensegrity structures from DNA | Full text - Self-assembly of three-dimensional prestressed tensegrity structures from DNA | PDF (5,647 KB) - Self-assembly of three-dimensional prestressed tensegrity structures from DNA | Supplementary information
Letter:
Folding and cutting DNA into reconfigurable topological nanostructures
Dongran Han, Suchetan Pal, Yan Liu & Hao Yan
doi:10.1038/nnano.2010.193
Abstract - Folding and cutting DNA into reconfigurable topological nanostructures | Full text - Folding and cutting DNA into reconfigurable topological nanostructures | PDF (7,745 KB) - Folding and cutting DNA into reconfigurable topological nanostructures | Supplementary information
Organizing nanomaterials with DNA
Letter:
Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach
Evelyn Auyeung, Joshua I. Cutler, Robert J. Macfarlane, Matthew R. Jones, Jinsong Wu, George Liu, Ke Zhang, Kyle D. Osberg & Chad A. Mirkin
doi:10.1038/nnano.2011.222
Abstract - Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach | Full text - Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach | PDF (3,306 KB) - Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach | Supplementary information
Review article:
Building plasmonic nanostructures with DNA
Shawn J. Tan, Michael J. Campolongo, Dan Luo & Wenlong Cheng
doi:10.1038/nnano.2011.49
Abstract - Building plasmonic nanostructures with DNA | Full text - Building plasmonic nanostructures with DNA | PDF (1,252 KB) - Building plasmonic nanostructures with DNA
Letter:
Programmable self-assembly of metal ions inside artificial DNA duplexes
Kentaro Tanaka, Guido H. Clever, Yusuke Takezawa, Yasuyuki Yamada, Corinna Kaul, Mitsuhiko Shionoya & Thomas Carell
doi:10.1038/nnano.2006.141
Abstract - Programmable self�assembly of metal ions inside artificial DNA duplexes | Full text - Programmable self�assembly of metal ions inside artificial DNA duplexes | PDF (1,213 KB) - Programmable self�assembly of metal ions inside artificial DNA duplexes | Supplementary information
Letter:
Self–assembled DNA nanostructures for distance–dependent multivalent ligand–protein binding
Sherri Rinker, Yonggang Ke, Yan Liu, Rahul Chhabra & Hao Yan
doi:10.1038/nnano.2008.164
Abstract - Self–assembled DNA nanostructures for distance�dependent multivalent ligand�protein binding | Full text - Self–assembled DNA nanostructures for distance�dependent multivalent ligand�protein binding | PDF (495 KB) - Self–assembled DNA nanostructures for distance�dependent multivalent ligand�protein binding | Supplementary information
Article:
Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates
Hareem T. Maune, Si-ping Han, Robert D. Barish, Marc Bockrath, William A. Goddard III, Paul W. K. Rothemund & Erik Winfree
doi:10.1038/nnano.2009.311
Abstract - Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates | Full text - Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates | PDF (846 KB) - Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates | Supplementary information
Letter:
Switching binary states of nanoparticle superlattices and dimer clusters by DNA strands
Mathew M. Maye, Mudalige Thilak Kumara, Dmytro Nykypanchuk, William B. Sherman & Oleg Gang
doi:10.1038/nnano.2009.378
Abstract - Switching binary states of nanoparticle superlattices and dimer clusters by DNA strands | Full text - Switching binary states of nanoparticle superlattices and dimer clusters by DNA strands | PDF (1,483 KB) - Switching binary states of nanoparticle superlattices and dimer clusters by DNA strands | Supplementary information
Letter:
Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami
Albert M. Hung, Christine M. Micheel, Luisa D. Bozano, Lucas W. Osterbur, Greg M. Wallraff & Jennifer N. Cha
doi:10.1038/nnano.2009.450
Abstract - Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami | Full text - Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami | PDF (2,777 KB) - Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami | Supplementary information
Letter:
DNA-based programming of quantum dot valency, self-assembly and luminescence
Grigory Tikhomirov, Sjoerd Hoogland, P. E. Lee, Armin Fischer, Edward H. Sargent & Shana O. Kelley
doi:10.1038/nnano.2011.100
Abstract - DNA-based programming of quantum dot valency, self-assembly and luminescence |
Full text - DNA-based programming of quantum dot valency, self-assembly and luminescence |
PDF (1,415 KB) - DNA-based programming of quantum dot valency, self-assembly and luminescence |
Supplementary information
See also: News and Views by Liu
Functional DNA nanostructures
Letter:
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
H Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanouil D. Karagiannis, Alfica Sehgal, William Querbes, Christopher S. Zurenko, Muthusamy Jayaraman, Chang G. Peng, Klaus Charisse, Anna Borodovsky, Muthiah Manoharan, Jessica S. Donahoe, Jessica Truelove, Matthias Nahrendorf, Robert Langer & Daniel G. Anderson
doi:10.1038/nnano.2012.73
Abstract - Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery |
Full text - Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery |
PDF (1,425 KB) - Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery |
Supplementary information
See also:
News & Views by Bhatia et al
Letter:
Multifunctional nanoarchitectures from DNA-based ABC monomers
Jong B. Lee, Young H. Roh, Soong Ho Um, Hisakage Funabashi, Wenlong Cheng, Judy J. Cha, Pichamon Kiatwuthinon, David A. Muller & Dan Luo
doi:10.1038/nnano.2009.93
Abstract - Multifunctional nanoarchitectures from DNA-based ABC monomers | Full text - Multifunctional nanoarchitectures from DNA-based ABC monomers | PDF (1,814 KB) - Multifunctional nanoarchitectures from DNA-based ABC monomers | Supplementary information
Letter:
Single-molecule chemical reactions on DNA origami
Niels V. Voigt, Thomas Tørring, Alexandru Rotaru, Mikkel F. Jacobsen, Jens B. Ravnsbæk, Ramesh Subramani, Wael Mamdouh, Jørgen Kjems, Andriy Mokhir, Flemming Besenbacher & Kurt Vesterager Gothelf
doi:10.1038/nnano.2010.5
Abstract - Single-molecule chemical reactions on DNA origami | Full text - Single-molecule chemical reactions on DNA origami | PDF (695 KB) - Single-molecule chemical reactions on DNA origami | Supplementary information
DNA nanomachines
Letter:
A DNA-based molecular motor that can navigate a network of tracks
Shelley F. J. Wickham, Jonathan Bath, Yousuke Katsuda, Masayuki Endo, Kumi Hidaka, Hiroshi Sugiyama & Andrew J. Turberfield
doi:10.1038/nnano.2011.253
Abstract - A DNA-based molecular motor that can navigate a network of tracks | Full text - A DNA-based molecular motor that can navigate a network of tracks | PDF (932 KB) - A DNA-based molecular motor that can navigate a network of tracks | Supplementary information
Review article:
DNA nanomachines
Jonathan Bath & Andrew J. Turberfield
doi:10.1038/nnano.2007.104
Abstract - DNA nanomachines | Full text - DNA nanomachines | PDF (1,041 KB) - DNA nanomachines
Letter:
An autonomous polymerization motor powered by DNA hybridization
Suvir Venkataraman, Robert M. Dirks, Paul W. K. Rothemund, Erik Winfree & Niles A. Pierce
doi:10.1038/nnano.2007.225
Abstract - An autonomous polymerization motor powered by DNA hybridization | Full text - An autonomous polymerization motor powered by DNA hybridization | PDF (721 KB) - An autonomous polymerization motor powered by DNA hybridization | Supplementary information
Article:
A DNA nanomachine that maps spatial and temporal pH changes inside living cells
Souvik Modi, Swetha M. G., Debanjan Goswami, Gagan D. Gupta, Satyajit Mayor & Yamuna Krishnan
doi:10.1038/nnano.2009.83
Abstract - A DNA nanomachine that maps spatial and temporal pH changes inside living cells |
Full text - A DNA nanomachine that maps spatial and temporal pH changes inside living cells | PDF (820 KB) - A DNA nanomachine that maps spatial and temporal pH changes inside living cells |
Supplementary information
See also: News and Views by Ishitsuka & Ha
Article:
A double-stranded DNA rotaxane
Damian Ackermann, Thorsten L. Schmidt, Jeffrey S. Hannam, Chandra S. Purohit, Alexander Heckel & Michael Famulok
doi:10.1038/nnano.2010.65
Abstract - A double-stranded DNA rotaxane | Full text - A double-stranded DNA rotaxane | PDF (3,913 KB) - A double-stranded DNA rotaxane | Supplementary information
Letter:
Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker
Yu He & David R. Liu
doi:10.1038/nnano.2010.190
Abstract - Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker |
Full text - Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker | PDF (781 KB) - Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker |
Supplementary information
See also: News and Views by Rotaru and Gothelf
Letter:
Direct observation of stepwise movement of a synthetic molecular transporter
Shelley F. J. Wickham, Masayuki Endo, Yousuke Katsuda, Kumi Hidaka, Jonathan Bath, Hiroshi Sugiyama & Andrew J. Turberfield
doi:10.1038/nnano.2010.284
Abstract - Direct observation of stepwise movement of a synthetic molecular transporter | Full text - Direct observation of stepwise movement of a synthetic molecular transporter | PDF (1,543 KB) - Direct observation of stepwise movement of a synthetic molecular transporter | Supplementary information
DNA computing
Letter:
Molecular implementation of simple logic programs
Tom Ran, Shai Kaplan & Ehud Shapiro
doi:10.1038/nnano.2009.203
Abstract - Molecular implementation of simple logic programs |
Full text - Molecular implementation of simple logic programs | PDF (754 KB) - Molecular implementation of simple logic programs |
Supplementary information
See also: News and Views by Stefanovic
Letter:
DNA computing circuits using libraries of DNAzyme subunits
Johann Elbaz, Oleg Lioubashevski, Fuan Wang, Françoise Remacle, Raphael D. Levine & Itamar Willner
doi:10.1038/nnano.2010.88
Abstract - DNA computing circuits using libraries of DNAzyme subunits | Full text - DNA computing circuits using libraries of DNAzyme subunits | PDF (641 KB) - DNA computing circuits using libraries of DNAzyme subunits | Supplementary information
Letter:
Training a molecular automaton to play a game
Renjun Pei, Elizabeth Matamoros, Manhong Liu, Darko Stefanovic & Milan N. Stojanovic
doi:10.1038/nnano.2010.194
Abstract - Training a molecular automaton to play a game |
Full text - Training a molecular automaton to play a game | PDF (594 KB) - Training a molecular automaton to play a game |
Supplementary information
See also: News and Views by Privman
News & Views:
Biocomputing: DNA computes a square root
Yaakov Benenson
doi:10.1038/nnano.2011.128
Abstract - Biocomputing: DNA computes a square root | Full text - Biocomputing: DNA computes a square root | PDF (287 KB) - Biocomputing: DNA computes a square root
RNA nanotechnology
Review article:
The emerging field of RNA nanotechnology
Peixuan Guo
doi:10.1038/nnano.2010.231
Abstract - The emerging field of RNA nanotechnology | Full text - The emerging field of RNA nanotechnology | PDF (669 KB) - The emerging field of RNA nanotechnology
Article:
In vitro assembly of cubic RNA-based scaffolds designed in silico
Kirill A. Afonin, Eckart Bindewald, Alan J. Yaghoubian, Neil Voss, Erica Jacovetty, Bruce A. Shapiro & Luc Jaeger
doi:10.1038/nnano.2010.160
Abstract - In vitro assembly of cubic RNA-based scaffolds designed in silico |
Full text - In vitro assembly of cubic RNA-based scaffolds designed in silico | PDF (2,604 KB) - In vitro assembly of cubic RNA-based scaffolds designed in silico |
Supplementary information
See also: News and Views by Famulok & Ackermann
Article:
Thermodynamically stable RNA three-way junction as a platform for constructing multifunctional nanoparticles for delivery of therapeutics
Dan Shu, Yi Shu, Farzin Haque, Sherine Abdelmawla and Peixuan Guo
doi:10.1038/nnano.2011.105
Abstract - Thermodynamically stable RNA three-way junction as a platform for constructing multifunctional nanoparticles for delivery of therapeutics | Full text - Thermodynamically stable RNA three-way junction as a platform for constructing multifunctional nanoparticles for delivery of therapeutics | PDF (4,652 KB) - Thermodynamically stable RNA three-way junction as a platform for constructing multifunctional nanoparticles for delivery of therapeutics